The ADPRH Polyclonal Antibody (CAB6277) is a key tool for research involving ADPRH, a critical enzyme involved in the regulation of ADP-ribose metabolism. This polyclonal antibody, raised in rabbits, is specifically designed for use in Western blot applications and is highly reactive with human samples. By targeting the ADPRH protein, researchers can accurately detect and analyze its expression in a variety of cell types, making it an essential tool for studies in molecular biology and biochemistry.ADPRH plays a crucial role in cellular processes such as DNA repair and gene expression regulation by modulating the levels of ADP-ribose, a key signaling molecule involved in various cellular pathways.
Dysregulation of ADPRH activity has been implicated in diseases such as cancer, neurodegenerative disorders, and metabolic diseases, making it an attractive target for drug development and therapeutic interventions.By using the ADPRH Polyclonal Antibody, researchers can gain valuable insights into the function and regulation of ADPRH, paving the way for advancements in drug discovery and personalized medicine. This antibody is a valuable tool for scientists exploring the complex role of ADPRH in health and disease, ultimately contributing to our understanding of cellular processes and potential treatment strategies.
Product Name:
ADPRH Rabbit Polyclonal Antibody
SKU:
CAB6277
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 180-270 of human ADPRH (NP_001116.1).
The enzyme encoded by this gene catalyzes removal of mono-ADP-ribose from arginine residues of proteins in the ADP-ribosylation cycle. Unlike the rat and mouse enzymes that require DTT for maximal activity, the human enzyme is DTT-independent. Alternatively spliced transcript variants that encode different protein isoforms have been described.
Purification Method:
Affinity purification
Gene ID:
141
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ADPRH antibody (CAB6277) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
