The Adora3 Antibody (PAC023513) is a valuable tool for researchers studying the adenosine A3 receptor, a G protein-coupled receptor involved in immunomodulation and inflammation. This polyclonal antibody, raised against the Adora3 protein, is highly specific for human samples and is validated for use in Western blotting applications. It binds to the Adora3 receptor with high affinity, allowing for accurate detection and analysis in various cell types.The adenosine A3 receptor is known for its anti-inflammatory and immunosuppressive effects, making it a potential target for therapeutic interventions in conditions such as autoimmune diseases and chronic inflammation.
By studying the expression and activity of Adora3, researchers can gain insights into how this receptor influences immune responses and potentially develop novel treatments that target its signaling pathways.In conclusion, the Adora3 Antibody (PAC023513) is a valuable tool for investigating the role of the adenosine A3 receptor in immune regulation and inflammatory processes. Its specificity and sensitivity make it an ideal choice for research in immunology, cancer biology, and drug development.
Fusion protein corresponding to a region derived from internal residues of human Adenosine receptor A3
Form:
Liquid
Storage Buffer:
Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Purification Method:
Antigen Affinity Purified
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 10%SDS-PAGE Lysates (from left to right): Mouse testis tissue Amount of lysate: 20ug per lane Primary antibody: 1/100 dilution Secondary antibody dilution: 1/8000 Exposure time: 1 minute.
Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue using at dilution 1/20.
Background:
This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms:
A3AR; AD026
UniProt Protein Function:
ADORA3: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 1p13.2Cellular Component: mast cell granule; integral to plasma membrane; plasma membraneMolecular Function: adenosine receptor activity, G-protein coupledBiological Process: positive regulation of phosphoinositide 3-kinase cascade; histamine secretion by mast cell; positive regulation of leukocyte migration; adenylate cyclase activation; response to wounding; positive regulation of mast cell degranulation; positive regulation of calcium-mediated signaling; signal transduction; inflammatory response; adenosine receptor signaling pathway; regulation of heart contraction; positive regulation of inflammatory response
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Alternative splicing results in multiple transcript variants. This gene shares its 5' terminal exon with some transcripts from overlapping GeneID:57413, which encodes an immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014]
