The Adora3 Antibody (PAC06237) is a polyclonal antibody designed for research involving Adora3, a cell surface receptor that plays a key role in the regulation of immune responses. This antibody, developed through the use of cutting-edge technology, has been validated for use in various applications, including Western blotting. It specifically targets the Adora3 protein, allowing for accurate detection and analysis in a variety of cell types.Adora3 is known for its involvement in mediating inflammatory responses and modulating immune function. Its role in immune regulation makes it a promising target for research in immunology, cancer biology, and other related fields.
Understanding the function of Adora3 can provide valuable insights into the development of therapies for conditions such as cancer, autoimmune disorders, and chronic inflammatory diseases.Overall, the Adora3 Antibody (PAC06237) offers researchers a reliable tool for studying the role of Adora3 in immune regulation and disease pathogenesis. Its high specificity and sensitivity make it an ideal choice for studies aiming to uncover the mechanisms underlying immune responses and their dysregulation in various pathological conditions.
Synthesized peptide derived from the C-terminal region of human Adenosine A3-R.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western Blot analysis of MCF7 HELA PC12 cells using Adenosine A3-R Polyclonal Antibody.
Western Blot analysis of MCF7 cells using Adenosine A3-R Polyclonal Antibody.
Synonyms:
ADORA3; Adenosine receptor A3
UniProt Protein Function:
ADORA3: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 1p13.2Cellular Component: mast cell granule; integral to plasma membrane; plasma membraneMolecular Function: adenosine receptor activity, G-protein coupledBiological Process: positive regulation of phosphoinositide 3-kinase cascade; histamine secretion by mast cell; positive regulation of leukocyte migration; adenylate cyclase activation; response to wounding; positive regulation of mast cell degranulation; positive regulation of calcium-mediated signaling; signal transduction; inflammatory response; adenosine receptor signaling pathway; regulation of heart contraction; positive regulation of inflammatory response
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Alternative splicing results in multiple transcript variants. This gene shares its 5' terminal exon with some transcripts from overlapping GeneID:57413, which encodes an immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014]
