The ADO Antibody (PACO58340) is a high-quality polyclonal antibody designed for research purposes involving ADO, a cell surface molecule known for its immune modulatory functions. This antibody, produced using innovative technology, is highly specific and reactive with human samples, making it a reliable tool for research studies.ADO, also known as adenosine deaminase, is a key enzyme involved in purine metabolism and plays a crucial role in regulating immune responses. The ADO Antibody binds specifically to the ADO protein, allowing for accurate detection and analysis in a variety of cell types.
This makes it a valuable asset for researchers studying immunology, inflammation, and related fields.The ADO Antibody is validated for use in Western blot applications, providing clear and reliable results for researchers. Its ability to target and detect the ADO protein makes it an essential tool for studies focusing on immune regulation, inflammatory diseases, and cancer research. By understanding the functions of ADO, researchers can gain insights into potential therapeutic strategies for various immune-related conditions.
Antibody Name:
ADO Antibody (PACO58340)
Antibody SKU:
PACO58340
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:200-1:500
Species Reactivity:
Human
Immunogen:
Recombinant Human 2-aminoethanethiol dioxygenase protein (137-270AA)
IHC image of PACO58340 diluted at 1:400 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Protein type:EC 1.13.11.19; Oxidoreductase; Other Amino Acids Metabolism - taurine and hypotaurine
Chromosomal Location of Human Ortholog: 10q21.3
Cellular Component: mitochondrion
Molecular Function:metal ion binding; cysteamine dioxygenase activity
NCBI Summary:
Human thiol dioxygenases include cysteine dioxygenase (CDO; MIM 603943) and cysteamine (2-aminoethanethiol) dioxygenase (ADO; EC 1.13.11.19). CDO adds 2 oxygen atoms to free cysteine, whereas ADO adds 2 oxygen atoms to free cysteamine to form hypotaurine (Dominy et al., 2007 [PubMed 17581819]).[supplied by OMIM, Mar 2008]
