The ADM2 Polyclonal Antibody (PAC017493) is a valuable tool for researchers studying ADM2, a protein involved in various cellular functions. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the ADM2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an ideal choice for studies in molecular biology and cell signaling research.ADM2, also known as adrenomedullin 2, is a peptide hormone that plays a role in various physiological processes such as vasodilation, regulation of blood pressure, and cell growth.
Its involvement in these pathways makes it a potential target for research in cardiovascular disease, cancer, and other conditions where dysregulation of these processes may occur. Investigating the functions of ADM2 can provide valuable insights for the development of potential therapeutic interventions targeting these pathways.Overall, the ADM2 Polyclonal Antibody is a reliable tool for researchers looking to study the role of ADM2 in various cellular processes and diseases. Its high specificity and reactivity with human samples make it a valuable asset for advancing research in the fields of molecular biology and cell signaling.
Antibody Name:
ADM2 Antibody (PACO17493)
Antibody SKU:
PACO17493
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human ADM2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17493(ADM2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO17493(ADM2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a protein which is a member of the calcitonin-related hormones. The encoded protein is involved in maintaining homeostasis in many tissues, acting via CRLR/RAMP receptor (calcitonin receptor-like receptor/receptor activity-modifying protein) complexes. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Synonyms:
adrenomedullin 2
UniProt Protein Function:
ADM2: IMDL and IMDS may play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway. Belongs to the adrenomedullin family.Protein type: Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 22q13.33Cellular Component: extracellular regionMolecular Function: protein complex bindingBiological Process: angiogenesis; positive regulation of angiogenesis; protein amino acid phosphorylation
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the calcitonin gene-related peptide (CGRP)/calcitonin family of hormones that play a role in the regulation of cardiovascular homeostasis, prolactin release, anti-diuresis, anti-natriuresis, and regulation of food and water intake. The encoded protein is proteolytically processed to generate one or more biologically active peptides. [provided by RefSeq, Jul 2015]
