The ADM2 Polyclonal Antibody (PACO17492) is a valuable tool for researchers studying the ADM2 protein, a key player in immune regulation and inflammatory responses. Raised in rabbits, this antibody is highly specific to human samples and has been validated for Western blot applications. By binding to the ADM2 protein, this antibody enables precise detection and analysis in various cell types, making it an essential tool for studies in immunology, inflammation, and cancer research.ADM2, also known as adrenomedullin 2, is a crucial mediator of inflammation and immune responses, making it a promising target for the development of therapies for conditions such as cancer, autoimmune diseases, and chronic inflammatory disorders.
Understanding the role of ADM2 in immune modulation is essential for advancing our knowledge of these diseases and developing effective treatments that target this pathway. The ADM2 Polyclonal Antibody (PACO17492) is a reliable and specific tool for researchers seeking to explore the functions of ADM2 in health and disease.
Antibody Name:
ADM2 Antibody (PACO17492)
Antibody SKU:
PACO17492
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human ADM2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO17492(ADM2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17492(ADM2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a protein which is a member of the calcitonin-related hormones. The encoded protein is involved in maintaining homeostasis in many tissues, acting via CRLR/RAMP receptor (calcitonin receptor-like receptor/receptor activity-modifying protein) complexes. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Synonyms:
adrenomedullin 2
UniProt Protein Function:
ADM2: IMDL and IMDS may play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway. Belongs to the adrenomedullin family.Protein type: Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 22q13.33Cellular Component: extracellular regionMolecular Function: protein complex bindingBiological Process: angiogenesis; positive regulation of angiogenesis; protein amino acid phosphorylation
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the calcitonin gene-related peptide (CGRP)/calcitonin family of hormones that play a role in the regulation of cardiovascular homeostasis, prolactin release, anti-diuresis, anti-natriuresis, and regulation of food and water intake. The encoded protein is proteolytically processed to generate one or more biologically active peptides. [provided by RefSeq, Jul 2015]
