The AdipoQ Polyclonal Antibody (PAC035942) is a crucial tool for researchers studying adiponectin, a protein involved in regulating metabolism and inflammation. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. It binds to the AdipoQ protein, allowing for precise detection and analysis in various cell types, making it an essential component for studies in diabetes, obesity, cardiovascular disease, and other metabolic disorders.
Adiponectin, also known as adipocyte complement-related protein of 30 kDa (ACRP30), plays a key role in adipocyte function and insulin sensitivity. Its involvement in regulating glucose and lipid metabolism makes it a promising target for therapeutic interventions in metabolic diseases. The AdipoQ antibody is essential for investigating the function and regulation of adiponectin, providing valuable insights into the mechanisms underlying metabolic disorders and potential treatments.
Western blot. All lanes: ADIPOQ antibody at 2µg/ml + Recombinant Adiponectin protein 0.1µg. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 27 kDa. Observed band size: 27 kDa.
Background:
Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid, combustion. Antagonizes TNF-α by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW ().
