The ADH7 Polyclonal Antibody (CAB7871) is a valuable tool for researchers studying alcohol dehydrogenase 7 (ADH7), an enzyme involved in the metabolism of alcohol and retinol. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blotting.ADH7 plays a crucial role in the breakdown of ethanol and retinol in the body, making it a key player in alcohol metabolism and vitamin A metabolism. Dysregulation of ADH7 has been linked to various health conditions, including alcohol dependence and vitamin A deficiency disorders.
Research into the function and regulation of ADH7 is essential for gaining insights into these physiological processes and potential therapeutic strategies.By utilizing the ADH7 Polyclonal Antibody, researchers can detect and analyze ADH7 protein expression in different cell types and tissues, facilitating studies in alcohol metabolism, vitamin A metabolism, and related disorders. This antibody is a valuable tool for investigations in the fields of biochemistry, pharmacology, and toxicology, offering insights into the role of ADH7 in health and disease.
Product Name:
ADH7 Rabbit Polyclonal Antibody
SKU:
CAB7871
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-386 of human ADH7 (NP_000664.2).
This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
131
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ADH7 antibody (CAB7871) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
