The ADH6 Polyclonal Antibody (PACO07617) is a valuable tool for researchers studying ADH6, a member of the alcohol dehydrogenase enzyme family involved in alcohol metabolism. This antibody, generated in rabbits, shows high specificity for human samples and is suitable for use in Western blotting and immunohistochemistry applications. By targeting the ADH6 protein, this antibody allows for the detection and analysis of ADH6 expression in various tissues and cell types, making it an ideal choice for studies related to alcohol metabolism, liver function, and metabolic disorders.
ADH6, also known as alcohol dehydrogenase 6, plays a crucial role in the breakdown of ethanol and other alcohols in the body. Understanding the function and regulation of ADH6 is essential for investigating alcohol metabolism, liver diseases, and the impact of alcohol consumption on human health. This antibody provides researchers with a reliable tool to explore the role of ADH6 in these processes and may lead to advancements in the treatment and management of alcohol-related disorders.
ADH6: class V alcohol dehydrogenase, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This gene is expressed in the stomach as well as in the liver, and it contains a glucocorticoid response element upstream of its 5' UTR, which is a steroid hormone receptor binding site. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]Protein type: Cofactor and Vitamin Metabolism - retinol; Amino Acid Metabolism - tyrosine; EC 1.1.1.1; Oxidoreductase; Xenobiotic Metabolism - metabolism by cytochrome P450; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Lipid Metabolism - fatty acid; Carbohydrate Metabolism - glycolysis and gluconeogenesisChromosomal Location of Human Ortholog: 4q23Cellular Component: cytosolMolecular Function: alcohol dehydrogenase activity; alcohol dehydrogenase activity, zinc-dependentBiological Process: ethanol oxidation; response to ethanol
UniProt Protein Details:
NCBI Summary:
This gene encodes class V alcohol dehydrogenase, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. This gene is expressed in the stomach as well as in the liver, and it contains a glucocorticoid response element upstream of its 5' UTR, which is a steroid hormone receptor binding site. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
