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ADH1C Rabbit Polyclonal Antibody (CAB8081)

SKU:
CAB8081
Product Type:
Antibody
Applications:
WB
IHC
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
  • Cell Biology Antibodies 11 Anti-ADH1C Antibody CAB8081
  • Cell Biology Antibodies 11 Anti-ADH1C Antibody CAB8081
  • Cell Biology Antibodies 11 Anti-ADH1C Antibody CAB8081
€139 - €419
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Description

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ADH1C Rabbit Polyclonal Antibody (CAB8081)

The ADH1C Polyclonal Antibody (CAB8081) is a valuable tool for researchers studying alcohol dehydrogenase 1C (ADH1C), an important enzyme involved in the metabolism of alcohol. This antibody is raised in rabbits and is highly reactive with human samples, making it ideal for use in Western blot applications. By binding specifically to the ADH1C protein, this antibody enables the detection and analysis of ADH1C in various cell types, facilitating research in areas like alcohol metabolism, liver disease, and alcohol-related health effects.ADH1C is a key player in the breakdown of alcohol in the body, converting ethanol into acetaldehyde, a potentially toxic substance.

Variations in the ADH1C gene have been linked to differences in alcohol metabolism and susceptibility to alcohol-related health problems. Understanding the role of ADH1C in alcohol metabolism and its implications for health and disease is essential for developing strategies to prevent and treat alcohol-related disorders. The ADH1C Polyclonal Antibody (CAB8081) provides researchers with a reliable tool for investigating the function and regulation of ADH1C in various experimental settings.

Product Name:ADH1C Rabbit Polyclonal Antibody
SKU:CAB8081
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-375 of human ADH1C (NP_000660.1).
Sequence:MSTA GKVI KCKA AVLW ELKK PFSI EEVE VAPP KAHE VRIK MVAA GICR SDEH VVSG NLVT PLPV ILGH EAAG IVES VGEG VTTV KPGD KVIP LFTP QCGK CRIC KNPE SNYC LKND LGNP RGTL QDGT RRFT CSGK PIHH FVGV STFS QYTV VDEN AVAK IDAA SPLE KVCL IGCG FSTG YGSA VKVA KVTP GSTC AVFG LGGV GLSV VMGC KAAG AARI IAVD INKD KFAK AKEL GATE CINP QDYK KPIQ EVLK EMTD GGVD FSFE VIGR LDTM MASL LCCH EACG TSVI VGVP PDSQ NLSI NPML LLTG RTWK GAIF GGFK SKES VPKL VADF MAKK FSLD ALIT NILP FEKI NEGF DLLR SGKS IRTV LTF
Tested Applications:WB IHC-P ELISA
Recommended Dilution:WB,1:500 - 1:2000 IHC-P,1:50 - 1:200
Synonyms:ADH3; ADH1C
Positive Sample:A-549,HepG2,293T
Conjugate:Unconjugated
Cellular Localization:Cytoplasm.
Calculated MW:40kDa
Observed MW:45kDa

This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation to acetaldehyde, thus playing a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. An association between ADH1C polymorphism and alcohol dependence has not been established.

Purification Method:Affinity purification
Gene ID:126
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using ADH1C Rabbit pAb (CAB8081) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 10s.

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