ADD1/ADD2 Antibody (PACO06234)
- SKU:
- PACO06234
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- IF
- IP
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
ADD1/ADD2 Antibody (PACO06234)
The ADD1/ADD2 Antibody (PACO06234) is a key tool for researchers studying the ADD1 and ADD2 proteins, which are essential components in the assembly of spectrin-actin network in red blood cells. This polyclonal antibody is produced in rabbits and exhibits high specificity and reactivity for human samples, making it suitable for a range of applications such as Western blotting and immunofluorescence.ADD1 and ADD2 are crucial for maintaining the structural integrity of red blood cells and mutations in these genes have been linked to various blood disorders, including hereditary elliptocytosis and hereditary spherocytosis.
By targeting these proteins with the PACO06234 antibody, researchers can gain valuable insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets for treatment.
| Antibody Name: | ADD1/ADD2 Antibody (PACO06234) |
| Antibody SKU: | PACO06234 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF, IP |
| Recommended Dilutions: | ELISA:1:40000, WB:1:500-1:2000, IHC:1:100-1:300, IP:2-5ug, IF:1:200-1:1000, |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human Adducin α / β around the non-phosphorylation site of S726/713. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot analysis of HELA PC12 NIH-3T3 cells using Adducin alpha / beta Polyclonal Antibody. |
 | Western Blot analysis of HELA cells using Adducin alpha / beta Polyclonal Antibody. |
| Synonyms: | ADD1; ADDA; α-adducin; Erythrocyte adducin subunit α; ADD2; ADDB; β-adducin; Erythrocyte adducin subunit β |
| UniProt Protein Function: | Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. |
| NCBI Summary: | Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, and gamma). Adducin acts as a heterodimer of the related alpha, beta, or gamma subunits. The protein encoded by this gene represents the alpha subunit. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. [provided by RefSeq, Aug 2017] |
| UniProt Code: | P35611 |
| NCBI GenInfo Identifier: | 12644231 |
| NCBI Gene ID: | 118 |
| NCBI Accession: | P35611.2 |
| UniProt Secondary Accession: | P35611,Q13734, Q14729, Q16156, Q86XM2, Q9UJB6, A2A3N8 A2A3P0, B4DI79, D3DVR3, D3DVR4, D3DVR5, |
| UniProt Related Accession: | P35611 |
| Molecular Weight: | 73,333 Da |
| NCBI Full Name: | Alpha-adducin |
| NCBI Synonym Full Names: | adducin 1 |
| NCBI Official Symbol: | ADD1Â Â |
| NCBI Official Synonym Symbols: | ADDAÂ Â |
| NCBI Protein Information: | alpha-adducin |
| UniProt Protein Name: | Alpha-adducin |
| UniProt Synonym Protein Names: | Erythrocyte adducin subunit alpha |
| Protein Family: | Alpha-adducin |
| UniProt Gene Name: | ADD1Â Â |
| Antibodies | ELISA Kits |
| Phospho-ADD1/ADD2 (S726/713) Antibody (PACO00316) | ADD1/2 Colorimetric Cell-Based ELISA Kit |
| ADD1/2 (Phospho-Ser726) Colorimetric Cell-Based ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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