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ADCY8 Antibody (PACO07611)

SKU:
PACO07611
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€459

Description

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ADCY8 Antibody (PACO07611)

The ADCY8 Polyclonal Antibody (PACO07611) is a valuable tool for researchers studying ADCY8, an enzyme involved in cellular signaling pathways. This antibody, generated in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the ADCY8 protein, this antibody enables the detection and analysis of ADCY8 expression in various cell types, making it ideal for investigations in cell signaling and disease mechanisms.ADCY8, also known as adenylyl cyclase type 8, plays a key role in intracellular signaling by catalyzing the production of cyclic AMP (cAMP).

This enzyme is implicated in regulating diverse cellular processes such as gene expression, metabolism, and neurotransmission. Dysregulation of ADCY8 activity has been associated with conditions including diabetes, cardiovascular disease, and neurological disorders. Therefore, elucidating the function and regulation of ADCY8 is essential for advancing our understanding of these diseases and developing targeted therapies.

Antibody Name:ADCY8 Antibody (PACO07611)
Antibody SKU:PACO07611
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human ADCY8
Form:Liquid
Storage Buffer:PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:adenylate cyclase 8 (brain);ADCY8;AC8;ADCY3;HBAC1 ;
UniProt Protein Function:ADCY8: This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
UniProt Protein Details:

Protein type:Nucleotide Metabolism - purine; Transporter; Membrane protein, multi-pass; Lyase; Membrane protein, integral; Transporter, aquaporin family; Adenylyl cyclase; EC 4.6.1.1

Chromosomal Location of Human Ortholog: 8q24

Cellular Component: membrane; integral to membrane; plasma membrane

Molecular Function:metal ion binding; calcium- and calmodulin-responsive adenylate cyclase activity; ATP binding; adenylate cyclase activity

Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; water transport; activation of protein kinase A; signal transduction; G-protein signaling, adenylate cyclase activating pathway; synaptic transmission; learning and/or memory; long-term memory; phospholipase C activation; energy reserve metabolic process; innate immune response; renal water homeostasis; cAMP biosynthetic process; G-protein signaling, adenylate cyclase inhibiting pathway; transmembrane transport

NCBI Summary:Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase [provided by RefSeq, Jul 2008]
UniProt Code:P40145
NCBI GenInfo Identifier:729242
NCBI Gene ID:114
NCBI Accession:P40145.1
UniProt Related Accession:P40145
Molecular Weight:1251
NCBI Full Name:Adenylate cyclase type 8
NCBI Synonym Full Names:adenylate cyclase 8 (brain)
NCBI Official Symbol:ADCY8  
NCBI Official Synonym Symbols:AC8; ADCY3; HBAC1  
NCBI Protein Information:adenylate cyclase type 8; adenylyl cyclase 8; ATP pyrophosphate-lyase 8; adenylyl cyclase-8, brain; adenylate cyclase type VIII; ca(2+)/calmodulin-activated adenylyl cyclase
UniProt Protein Name:Adenylate cyclase type 8
UniProt Synonym Protein Names:ATP pyrophosphate-lyase 8; Adenylate cyclase type VIII; Adenylyl cyclase 8; AC8; Ca(2+)/calmodulin-activated adenylyl cyclase
Protein Family:Adenylate cyclase
UniProt Gene Name:ADCY8  
UniProt Entry Name:ADCY8_HUMAN

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