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ADCY8 Antibody (PACO03396)

SKU:
PACO03396
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269

Description

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ADCY8 Antibody (PACO03396)

The ADCY8 Polyclonal Antibody (PACO03396) is a valuable tool for researchers studying ADCY8, an important enzyme involved in intracellular signaling pathways. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blotting and immunohistochemistry applications. By binding to the ADCY8 protein, the antibody allows for the detection and analysis of ADCY8 expression in various cell types, making it ideal for studies in cell signaling and signal transduction.ADCY8, also known as Adenylate Cyclase 8, plays a crucial role in the production of cyclic AMP (cAMP), a key messenger molecule involved in numerous cellular processes.

Dysregulation of ADCY8 has been implicated in various diseases, including cancer, cardiovascular disorders, and neurological conditions. Investigating the function of ADCY8 can provide valuable insights into the underlying mechanisms of these diseases and may lead to the development of novel therapeutic strategies targeting cAMP signaling pathways.

Antibody Name:ADCY8 Antibody
Antibody SKU:PACO03396
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC, IF
Recommended Dilutions:IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from the Internal region of human A Cyclase VIII.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:ADCY8; Adenylate cyclase type 8; ATP pyrophosphate-lyase 8; Adenylate cyclase type VIII; Adenylyl cyclase 8; AC8; Ca(2+)/calmodulin-activated adenylyl cyclase
UniProt Protein Function:ADCY8: This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
UniProt Protein Details:

Protein type:Nucleotide Metabolism - purine; Transporter; Membrane protein, multi-pass; Lyase; Membrane protein, integral; Transporter, aquaporin family; Adenylyl cyclase; EC 4.6.1.1

Chromosomal Location of Human Ortholog: 8q24

Cellular Component: membrane; integral to membrane; plasma membrane

Molecular Function:metal ion binding; calcium- and calmodulin-responsive adenylate cyclase activity; ATP binding; adenylate cyclase activity

Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; water transport; activation of protein kinase A; signal transduction; G-protein signaling, adenylate cyclase activating pathway; synaptic transmission; learning and/or memory; long-term memory; phospholipase C activation; energy reserve metabolic process; innate immune response; renal water homeostasis; cAMP biosynthetic process; G-protein signaling, adenylate cyclase inhibiting pathway; transmembrane transport

NCBI Summary:Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase [provided by RefSeq, Jul 2008]
UniProt Code:P40145
NCBI GenInfo Identifier:729242
NCBI Gene ID:114
NCBI Accession:P40145.1
UniProt Related Accession:P40145
Molecular Weight:1251
NCBI Full Name:Adenylate cyclase type 8
NCBI Synonym Full Names:adenylate cyclase 8 (brain)
NCBI Official Symbol:ADCY8  
NCBI Official Synonym Symbols:AC8; ADCY3; HBAC1  
NCBI Protein Information:adenylate cyclase type 8; adenylyl cyclase 8; ATP pyrophosphate-lyase 8; adenylyl cyclase-8, brain; adenylate cyclase type VIII; ca(2+)/calmodulin-activated adenylyl cyclase
UniProt Protein Name:Adenylate cyclase type 8
UniProt Synonym Protein Names:ATP pyrophosphate-lyase 8; Adenylate cyclase type VIII; Adenylyl cyclase 8; AC8; Ca(2+)/calmodulin-activated adenylyl cyclase
Protein Family:Adenylate cyclase
UniProt Gene Name:ADCY8  
UniProt Entry Name:ADCY8_HUMAN

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