The ADCY7 Polyclonal Antibody (PAC019066) is a valuable tool for researchers studying ADCY7, an enzyme involved in cellular signaling pathways, particularly in relation to cAMP production. This antibody is raised in rabbits and has been validated for use in Western blot applications, providing reliable detection and analysis of ADCY7 in various samples.ADCY7, also known as adenylate cyclase type 7, plays a crucial role in regulating intracellular levels of cAMP, a key secondary messenger involved in numerous physiological processes.
Dysregulation of ADCY7 has been implicated in diseases such as cancer, diabetes, and neurological disorders, making it a promising target for therapeutic development.By using the ADCY7 Polyclonal Antibody, researchers can gain valuable insights into the function and regulation of ADCY7 in different cell types and disease contexts. This antibody is a valuable tool for studies aiming to unravel the intricate signaling pathways controlled by ADCY7 and its potential as a therapeutic target in various pathological conditions.
Antibody Name:
ADCY7 Antibody (PACO19066)
Antibody SKU:
PACO19066
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human ADCY7
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO19066(ADCY7 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a membrane-bound adenylate cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences.
Synonyms:
adenylate cyclase 7
UniProt Protein Function:
ADCY7: This is a membrane-bound, calcium-inhibitable adenylyl cyclase. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.Protein type: Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin familyChromosomal Location of Human Ortholog: 16q12.1Cellular Component: integral to membrane; plasma membraneMolecular Function: adenylate cyclase activityBiological Process: activation of protein kinase A; adenylate cyclase activation; cAMP-mediated signaling; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, adenylate cyclase inhibiting pathway; positive regulation of cAMP biosynthetic process; renal water homeostasis
