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ADCY6/ADCY5 Antibody (PACO03386)

SKU:
PACO03386
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
Frequently bought together:

Description

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ADCY6/ADCY5 Antibody (PACO03386)

The ADCY6/ADCY5 Polyclonal Antibody (PACO03386) is a valuable tool for researchers studying ADCY6 and ADCY5 proteins, which play important roles in cellular signaling pathways. This antibody, produced in rabbits, is highly specific and sensitive to human samples, making it ideal for use in Western blotting and immunohistochemistry applications.ADCY6 and ADCY5 are key enzymes involved in the production of cyclic adenosine monophosphate (cAMP), a critical secondary messenger molecule that regulates various cellular processes, including metabolism, neurotransmission, and gene expression.

Dysregulation of ADCY6 and ADCY5 has been implicated in a variety of diseases, such as cancer, diabetes, and neurological disorders.By targeting ADCY6 and ADCY5 proteins, researchers can gain insights into the mechanisms underlying these diseases and potentially develop novel therapeutic strategies. The PACO03386 antibody enables precise detection and analysis of ADCY6 and ADCY5 proteins in different cell types, paving the way for advancements in biomedical research and drug development.

Antibody Name:ADCY6/ADCY5 Antibody
Antibody SKU:PACO03386
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC, IF
Recommended Dilutions:IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from the C-terminal region of human A Cyclase V/VI.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:ADCY6; KIAA0422; Adenylate cyclase type 6; ATP pyrophosphate-lyase 6; Adenylate cyclase type VI; Adenylyl cyclase 6; Ca(2+)-inhibitable adenylyl cyclase; ADCY5; Adenylate cyclase type 5; ATP pyrophosphate-lyase 5; Adenylate cyclase type V;
UniProt Protein Function:ADCY6: a membrane-associated enzyme that catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Expressed in normal thyroid and brain tissues, as well as some tumors; its expression is significantly higher in one hyperfunctioning thyroid tumor than in normal thyroid tissue. Alternative splicing generates 2 transcript variants.Protein type: Nucleotide Metabolism - purine; EC 4.6.1.1; Transporter; Lyase; Adenylyl cyclase; Membrane protein, multi-pass; Transporter, aquaporin family; Membrane protein, integralChromosomal Location of Human Ortholog: 12q12-q13Cellular Component: membrane; plasma membrane; integral to membrane; ciliumMolecular Function: protein binding; metal ion binding; protein kinase binding; ATP binding; adenylate cyclase activityBiological Process: epidermal growth factor receptor signaling pathway; synaptic transmission; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; phospholipase C activation; water transport; activation of protein kinase A; dopamine receptor signaling pathway; energy reserve metabolic process; innate immune response; renal water homeostasis; cAMP biosynthetic process; G-protein signaling, adenylate cyclase inhibiting pathway; signal transduction; transmembrane transport; G-protein signaling, adenylate cyclase activating pathwayDisease: Lethal Congenital Contracture Syndrome 8
UniProt Protein Details:
NCBI Summary:This gene encodes adenylate cyclase 6, which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). The expression of this gene is found in normal thyroid and brain tissues, as well as some tumors; and its expression is significantly higher in one hyperfunctioning thyroid tumor than in normal thyroid tissue. Alternative splicing generates 2 transcript variants. [provided by RefSeq, Jul 2008]
UniProt Code:O43306
NCBI GenInfo Identifier:12644065
NCBI Gene ID:112
NCBI Accession:O43306.2
UniProt Secondary Accession:O43306,Q9NR75, Q9UDB0
UniProt Related Accession:O43306
Molecular Weight:
NCBI Full Name:Adenylate cyclase type 6
NCBI Synonym Full Names:adenylate cyclase 6
NCBI Official Symbol:ADCY6  
NCBI Official Synonym Symbols:AC6  
NCBI Protein Information:adenylate cyclase type 6; ATP pyrophosphate-lyase 6; adenylate cyclase type VI; adenylyl cyclase 6; ca(2+)-inhibitable adenylyl cyclase
UniProt Protein Name:Adenylate cyclase type 6
UniProt Synonym Protein Names:ATP pyrophosphate-lyase 6; Adenylate cyclase type VI; Adenylyl cyclase 6; Ca(2+)-inhibitable adenylyl cyclase
Protein Family:Adenylate cyclase
UniProt Gene Name:ADCY6  
UniProt Entry Name:ADCY6_HUMAN

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