Anti-ADCY5 Antibody (PACO19065)

Antibody Name:	ADCY5 Antibody (PACO19065)
Antibody SKU:	PACO19065
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:10000, IHC:1:50-1:200
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide of human ADCY5

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19065(ADCY5 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
	The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19065(ADCY5 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs α subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi α subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene.

Synonyms:

adenylate cyclase 5

UniProt Protein Function:	ADCY5: This is a membrane-bound, calcium-inhibitable adenylyl cyclase. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Adenylyl cyclase; Nucleotide Metabolism - purine; Transporter, aquaporin family; EC 4.6.1.1; Transporter; Membrane protein, integral; LyaseChromosomal Location of Human Ortholog: 3q21.1Cellular Component: integral to membrane; plasma membraneMolecular Function: adenylate cyclase activity; adenylate cyclase binding; protein heterodimerization activityBiological Process: activation of protein kinase A; adenylate cyclase activation; cAMP biosynthetic process; cAMP-mediated signaling; elevation of cytosolic calcium ion concentration; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, adenylate cyclase inhibiting pathway; renal water homeostasisDisease: Dyskinesia, Familial, With Facial Myokymia
UniProt Protein Details:
NCBI Summary:	This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
UniProt Code:	O95622
NCBI GenInfo Identifier:	118572619
NCBI Gene ID:	111
NCBI Accession:	O95622.3
UniProt Secondary Accession:	O95622,Q7RTV7, Q8NFM3, B7Z8A6
UniProt Related Accession:	O95622
Molecular Weight:	102,606 Da
NCBI Full Name:	Adenylate cyclase type 5
NCBI Synonym Full Names:	adenylate cyclase 5
NCBI Official Symbol:	ADCY5
NCBI Official Synonym Symbols:	AC5; FDFM
NCBI Protein Information:	adenylate cyclase type 5
UniProt Protein Name:	Adenylate cyclase type 5
UniProt Synonym Protein Names:	ATP pyrophosphate-lyase 5; Adenylate cyclase type V; Adenylyl cyclase 5; AC5
Protein Family:	Adenylate cyclase
UniProt Gene Name:	ADCY5
UniProt Entry Name:	ADCY5_HUMAN

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)