ADCY5 Antibody (PACO19065)
- SKU:
- PACO19065
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
ADCY5 Antibody (PACO19065)
The ADCY5 Polyclonal Antibody (PACO19065) is a valuable tool for researchers studying ADCY5, an enzyme involved in the regulation of the cyclic AMP signaling pathway. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the ADCY5 protein, this antibody enables the detection and analysis of ADCY5 expression in a variety of cell types, making it ideal for studies in cell signaling, metabolism, and neurological disorders.ADCY5 is a critical player in intracellular signaling cascades, mediating the effects of hormones, neurotransmitters, and other extracellular signals on cellular function.
Dysregulation of ADCY5 activity has been implicated in a range of diseases, including obesity, diabetes, and neurological disorders such as Parkinson's disease and dystonia. Investigating the role of ADCY5 and its downstream signaling pathways is essential for understanding the pathophysiology of these conditions and identifying potential therapeutic targets.
| Antibody Name: | ADCY5 Antibody (PACO19065) |
| Antibody SKU: | PACO19065 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:50-1:200 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human ADCY5 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19065(ADCY5 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19065(ADCY5 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs α subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi α subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. |
| Synonyms: | adenylate cyclase 5 |
| UniProt Protein Function: | ADCY5: This is a membrane-bound, calcium-inhibitable adenylyl cyclase. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Adenylyl cyclase; Nucleotide Metabolism - purine; Transporter, aquaporin family; EC 4.6.1.1; Transporter; Membrane protein, integral; LyaseChromosomal Location of Human Ortholog: 3q21.1Cellular Component: integral to membrane; plasma membraneMolecular Function: adenylate cyclase activity; adenylate cyclase binding; protein heterodimerization activityBiological Process: activation of protein kinase A; adenylate cyclase activation; cAMP biosynthetic process; cAMP-mediated signaling; elevation of cytosolic calcium ion concentration; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, adenylate cyclase inhibiting pathway; renal water homeostasisDisease: Dyskinesia, Familial, With Facial Myokymia |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010] |
| UniProt Code: | O95622 |
| NCBI GenInfo Identifier: | 118572619 |
| NCBI Gene ID: | 111 |
| NCBI Accession: | O95622.3 |
| UniProt Secondary Accession: | O95622,Q7RTV7, Q8NFM3, B7Z8A6 |
| UniProt Related Accession: | O95622 |
| Molecular Weight: | 102,606 Da |
| NCBI Full Name: | Adenylate cyclase type 5 |
| NCBI Synonym Full Names: | adenylate cyclase 5 |
| NCBI Official Symbol: | ADCY5Â Â |
| NCBI Official Synonym Symbols: | AC5; FDFMÂ Â |
| NCBI Protein Information: | adenylate cyclase type 5 |
| UniProt Protein Name: | Adenylate cyclase type 5 |
| UniProt Synonym Protein Names: | ATP pyrophosphate-lyase 5; Adenylate cyclase type V; Adenylyl cyclase 5; AC5 |
| Protein Family: | Adenylate cyclase |
| UniProt Gene Name: | ADCY5Â Â |
| UniProt Entry Name: | ADCY5_HUMAN |
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