The ADCY5/ADCY6 Polyclonal Antibody (PACO6212) is a valuable tool for researchers studying ADCY5 and ADCY6 proteins, which are involved in the regulation of adenylate cyclase activity and intracellular cAMP levels. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot analysis.ADCY5 and ADCY6 are key enzymes in the production of cAMP, a second messenger molecule that plays a central role in signal transduction pathways. Dysregulation of cAMP signaling has been implicated in a variety of diseases, including cancer, neurological disorders, and metabolic conditions.
By targeting ADCY5 and ADCY6, researchers can gain insights into the mechanisms underlying these diseases and identify potential therapeutic targets.The ADCY5/ADCY6 Polyclonal Antibody is a valuable tool for studying the function and regulation of these important enzymes in various cell types. Its high specificity and sensitivity make it ideal for use in immunology, cell biology, and drug discovery research. By using this antibody, researchers can further their understanding of cAMP signaling pathways and their role in human health and disease.
Synthesized peptide derived from the C-terminal region of human A Cyclase V/VI.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western Blot analysis of HuvEc MCF7 PC12 cells using A Cyclase V/VI Polyclonal Antibody.
Western Blot analysis of COLO205 cells using A Cyclase V/VI Polyclonal Antibody.
Synonyms:
ADCY5; Adenylate cyclase type 5; ATP pyrophosphate-lyase 5; Adenylate cyclase type V; Adenylyl cyclase 5; ADCY6; KIAA0422; Adenylate cyclase type 6; ATP pyrophosphate-lyase 6; Adenylate cyclase type VI; Adenylyl cyclase 6; Ca(2+)-inhibitabl
UniProt Protein Function:
ADCY5: This is a membrane-bound, calcium-inhibitable adenylyl cyclase. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Adenylyl cyclase; Nucleotide Metabolism - purine; Transporter, aquaporin family; EC 4.6.1.1; Transporter; Membrane protein, integral; LyaseChromosomal Location of Human Ortholog: 3q21.1Cellular Component: integral to membrane; plasma membraneMolecular Function: adenylate cyclase activity; adenylate cyclase binding; protein heterodimerization activityBiological Process: activation of protein kinase A; adenylate cyclase activation; cAMP biosynthetic process; cAMP-mediated signaling; elevation of cytosolic calcium ion concentration; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, adenylate cyclase inhibiting pathway; renal water homeostasisDisease: Dyskinesia, Familial, With Facial Myokymia
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
