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Anti-ADCY2 Antibody (CAB9805)

SKU:
CAB9805
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Metabolism
€139 - €419
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Description

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Antibody Name:Anti-ADCY2 Antibody
Antibody SKU:CAB9805
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 430-600 of human ADCY2 (NP_065433.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:SH-SY5Y, Rat eye
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 430-600 of human ADCY2 (NP_065433.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VTLE HLNG AYKV EEGD GDIR DPYL KQHL VKTY FVIN PKGE RRSP QHLF RPRH TLDG AKMR ASVR MTRY LESW GAAK PFAH LHHR DSMT TENG KIST TDVP MGQH NFQN RTLR TKSQ KKRF EEEL NERM IQAI DGIN AQKQ WLKS EDIQ RISL LFYN KVLE KEYR ATAL PAF
Gene ID:108
Uniprot:Q08462
Cellular Location:Cell membrane, Cytoplasm, Membrane, Multi-pass membrane protein
Calculated MW:103kDa/123kDa
Observed MW:150kDa
Synonyms:ADCY2, AC2, HBAC2
Background:This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex.
UniProt Protein Function:ADCY2: This is a membrane-bound, calmodulin-insensitive adenylyl cyclase. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Adenylyl cyclase; Transporter, aquaporin family; Nucleotide Metabolism - purine; Membrane protein, multi-pass; EC 4.6.1.1; Transporter; Lyase

Chromosomal Location of Human Ortholog: 5p15.3

Cellular Component: cytoplasm; dendrite; integral to plasma membrane; intracellular; lipid raft; membrane; plasma membrane

Molecular Function:adenylate cyclase activity; adenylate cyclase binding; magnesium ion binding; manganese ion binding; protein heterodimerization activity

Biological Process: activation of protein kinase A; adenylate cyclase activation; cAMP biosynthetic process; cAMP-mediated signaling; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, adenylate cyclase inhibiting pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; renal water homeostasis

NCBI Summary:This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. [provided by RefSeq, Jul 2008]
UniProt Code:Q08462
NCBI GenInfo Identifier:118572617
NCBI Gene ID:108
NCBI Accession:Q08462.5
UniProt Secondary Accession:Q08462,Q2NKL8, Q9UDB2, Q9UPU2, B7Z2C1,
UniProt Related Accession:Q08462
Molecular Weight:103,158 Da
NCBI Full Name:Adenylate cyclase type 2
NCBI Synonym Full Names:adenylate cyclase 2
NCBI Official Symbol:ADCY2  
NCBI Official Synonym Symbols:AC2; HBAC2  
NCBI Protein Information:adenylate cyclase type 2
UniProt Protein Name:Adenylate cyclase type 2
UniProt Synonym Protein Names:ATP pyrophosphate-lyase 2; Adenylate cyclase type II; Adenylyl cyclase 2
Protein Family:Adenylate cyclase
UniProt Gene Name:ADCY2  
UniProt Entry Name:ADCY2_HUMAN
Anti-ADCY2 Polyclonal Antibody (CAB9805)Western blot analysis of extracts of various cell lines, using ADCY2 antibody (CAB9805) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.

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