The ADAR Polyclonal Antibody (CAB7869) is specifically designed for research involving the ADAR protein, an essential component in RNA editing processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the ADAR protein, researchers are able to detect and analyze its presence in various cell types, making it an ideal tool for studies in RNA editing, gene regulation, and molecular biology.ADAR, or adenosine deaminase acting on RNA, is a key enzyme involved in the modification of RNA molecules, particularly in editing adenosine to inosine. This process plays a crucial role in RNA function and regulation, impacting gene expression, protein diversity, and ultimately cellular functions.
The importance of ADAR in RNA editing makes it a target of interest in fields such as neuroscience, developmental biology, and virology, where RNA modifications have significant implications.Understanding the function and regulation of ADAR is essential for unraveling the complexity of RNA editing processes and its implications in various biological pathways. The ADAR Polyclonal Antibody (CAB7869) provides researchers with a reliable tool to study the expression and localization of the ADAR protein, enabling further insights into its role in RNA editing and related cellular processes.
Product Name:
ADAR1 Rabbit Polyclonal Antibody
SKU:
CAB7869
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 200-299 of human ADAR11 (NP_001102.2).
This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
103
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from 293F cells, using ADAR1 Rabbit pAb (CAB7869) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
