The ADAMTSL1 Polyclonal Antibody (CAB8073) is a valuable tool for researchers studying ADAMTSL1, a secreted glycoprotein involved in microfibril assembly and regulation of extracellular matrix structure. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the ADAMTSL1 protein, researchers can accurately detect and analyze its expression in various cell types, making it an essential component for studies in developmental biology and cardiovascular research.
ADAMTSL1 plays a crucial role in maintaining tissue integrity and function by modulating extracellular matrix composition. Dysregulation of ADAMTSL1 has been implicated in various pathological conditions, including connective tissue disorders and cardiovascular diseases. Investigating the function of ADAMTSL1 is essential for understanding its role in disease progression and developing targeted therapies to restore normal tissue structure and function.
Product Name:
ADAMTSL1 Rabbit Polyclonal Antibody
SKU:
CAB8073
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1483-1762 of human ADAMTSL1 (NP_001035362.3).
This gene encodes a secreted protein and member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family. This protein lacks the metalloproteinase and disintegrin-like domains, which are typical of the ADAMTS family, but contains other ADAMTS domains, including the thrombospondin type 1 motif. This protein may have important functions in the extracellular matrix. Alternative splicing results in multiple transcript variants encoding distinct proteins.
Purification Method:
Affinity purification
Gene ID:
92949
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ADAMTSL1 antibody (CAB8073) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.
