The ADAMTS7 Polyclonal Antibody (CAB17093) is a valuable tool for researchers studying ADAMTS7, a metalloproteinase enzyme involved in extracellular matrix remodeling and implicated in various diseases, including atherosclerosis and osteoarthritis. This rabbit-derived antibody offers high reactivity with human samples and has been validated for Western blot applications, enabling detection and analysis of the ADAMTS7 protein in different cell types.ADAMTS7 plays a crucial role in vascular and cartilage biology, influencing processes like angiogenesis and cartilage degradation. Its dysregulation has been linked to the pathogenesis of cardiovascular diseases and joint disorders, making it a promising target for therapeutic intervention.
By studying ADAMTS7 expression and activity, researchers can gain insights into disease mechanisms and potential treatment strategies.The ADAMTS7 Polyclonal Antibody is an essential tool for investigations into the function of this enzyme and its role in health and disease. With its specificity and reliability, this antibody is a valuable resource for studies in cardiovascular biology, orthopedics, and other fields where ADAMTS7 is a key player.
Product Name:
ADAMTS7 Rabbit Polyclonal Antibody
SKU:
CAB17093
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1600-1686 of human ADAMTS7 (NP_055087.2).
cell surface, endoplasmic reticulum lumen, extracellular region
Calculated MW:
184kDa
Observed MW:
200kDa
The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and may regulate vascular smooth muscle cell (VSMC) migration. Mutations in this gene may be associated with susceptibility to coronary artery disease.
Purification Method:
Affinity purification
Gene ID:
11173
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from SH-SY5Y cells, using ADAMTS7 Rabbit pAb (CAB17093) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 5min.
