The ADAMTS6 Polyclonal Antibody (PAC018517) is a valuable tool for researchers studying ADAMTS6, a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family of enzymes. ADAMTS6 is known for its role in extracellular matrix remodeling and tissue development, making it a key player in processes such as wound healing and cartilage formation.This antibody, generated in rabbits, exhibits high specificity and sensitivity for human samples, making it suitable for use in various research applications including Western blotting and immunohistochemistry. By targeting the ADAMTS6 protein, this antibody enables researchers to detect and analyze the expression of ADAMTS6 in different cell types and tissues, providing valuable insights into its functions and regulatory mechanisms.
Given its involvement in tissue remodeling and development, ADAMTS6 is of interest in various fields, including developmental biology, orthopedics, and regenerative medicine. Understanding the role of ADAMTS6 in physiological and pathological processes is essential for developing targeted therapies for conditions such as arthritis, cardiovascular disease, and cancer. The ADAMTS6 Polyclonal Antibody serves as a reliable tool for investigating the functions of this enzyme and its potential as a therapeutic target.
Antibody Name:
ADAMTS6 Antibody (PACO18517)
Antibody SKU:
PACO18517
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:5000, IHC:1:15-1:50
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human ADAMTS6
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO18517(ADAMTS6 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using PACO18517(ADAMTS6 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains.
Synonyms:
ADAM metallopeptidase with thrombospondin type 1 motif, 6
UniProt Protein Function:
ADAMTS6: a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. [provided by RefSeq, Jul 2008]
UniProt Protein Details:
Protein type:EC 3.4.24.-; Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted; Protease
Chromosomal Location of Human Ortholog: 5q12
Molecular Function:metallopeptidase activity
NCBI Summary:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Expression of this gene may be regulated by the cytokine TNF-alpha. [provided by RefSeq, Mar 2016]
