The ADAMTS6 Polyclonal Antibody (PAC018516) is a valuable tool for researchers studying the ADAMTS6 protein, a member of the ADAMTS family known for its role in extracellular matrix degradation and tissue remodeling. Raised in rabbits, this antibody is highly specific for human samples and has been validated for use in Western blot applications. By targeting the ADAMTS6 protein, this antibody allows for the detection and analysis of ADAMTS6 expression in various cell types, making it ideal for investigations in the fields of biology, medicine, and pharmacology.
ADAMTS6 is involved in diverse physiological processes, including tissue development, wound healing, and inflammation. Dysregulation of ADAMTS6 has been linked to various diseases, such as cancer, arthritis, and cardiovascular disorders. Therefore, understanding the function of ADAMTS6 is crucial for developing novel therapeutic strategies aimed at targeting this protein in disease management. The ADAMTS6 Polyclonal Antibody provides a reliable tool for further exploration of ADAMTS6 biology and its potential as a therapeutic target.
Antibody Name:
ADAMTS6 Antibody (PACO18516)
Antibody SKU:
PACO18516
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:5000, IHC:1:15-1:50
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human ADAMTS6
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO18516(ADAMTS6 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains.
Synonyms:
ADAM metallopeptidase with thrombospondin type 1 motif, 6
UniProt Protein Function:
ADAMTS6: a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. [provided by RefSeq, Jul 2008]
UniProt Protein Details:
Protein type:EC 3.4.24.-; Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted; Protease
Chromosomal Location of Human Ortholog: 5q12
Molecular Function:metallopeptidase activity
NCBI Summary:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Expression of this gene may be regulated by the cytokine TNF-alpha. [provided by RefSeq, Mar 2016]
