ADAMTS4 Rabbit Polyclonal Antibody (CAB2525)
- SKU:
- CAB2525
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | ADAMTS4 Rabbit Polyclonal Antibody |
SKU: | CAB2525 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 74-318 of human ADAMTS4 (NP_005090.3). |
Sequence: | GSGA PARL LCRL QAFG ETLL LELE QDSG VQVE GLTV QYLG QAPE LLGG AEPG TYLT GTIN GDPE SVAS LHWD GGAL LGVL QYRG AELH LQPL EGGT PNSA GGPG AHIL RRKS PASG QGPM CNVK APLG SPSP RPRR AKRF ASLS RFVE TLVV ADDK MAAF HGAG LKRY LLTV MAAA AKAF KHPS IRNP VSLV VTRL VILG SGEE GPQV GPSA AQTL RSFC AWQR GLNT PEDS DPDH FDTA ILFT R |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | ADMP-1; ADAMTS-2; ADAMTS-4; ADAMTS4 |
Positive Sample: | C6,Mouse liver,Mouse testis,Mouse brain,Rat brain,Rat uterus,Mouse heart |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted, extracellular matrix, extracellular space. |
Calculated MW: | 90kDa |
Observed MW: | 90kDa/ |
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The expression of this gene is upregulated in arthritic disease and this may contribute to disease progression through the degradation of aggrecan. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Purification Method: | Affinity purification |
Gene ID: | 9507 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |