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ADAMTS2 Antibody (PACO07203)

SKU:
PACO07203
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$323
Frequently bought together:

Description

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ADAMTS2 Antibody (PACO07203)

The ADAMTS2 Polyclonal Antibody (PACO07203) is specifically designed for research involving ADAMTS2, a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family of enzymes. The antibody, generated in rabbits, has high reactivity with human samples and has been validated for use in various applications, including Western blotting.ADAMTS2 is known for its role in extracellular matrix remodeling, specifically in collagen metabolism. It plays a critical role in collagen processing and can cleave various types of collagen, thereby influencing tissue development and repair.

The ADAMTS2 antibody binds specifically to the ADAMTS2 protein, allowing for detection and analysis in different cell types and tissues.Research on ADAMTS2 is important in understanding its function in processes like wound healing, tissue formation, and diseases related to collagen abnormalities. Its involvement in collagen metabolism makes it a potential target for therapeutic interventions in conditions such as fibrosis, arthritis, and cardiovascular diseases. Studying the activity of ADAMTS2 can provide insights into potential new treatment strategies for these disorders.

Antibody Name:ADAMTS2 Antibody (PACO07203)
Antibody SKU:PACO07203
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:ELISA:1:10000, WB:1:500-1:2000
Species Reactivity:Human
Immunogen:Synthesized peptide derived from the C-terminal region of human ADAMTS-2. at AA rangle: 1140-1211
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern blot analysis of HepG2 K562 Hela Colo using ADAMTS-2 antibody. Secondary antibody was diluted at 1:20000.
Synonyms:ADAMTS2; PCINP; PCPNI; A disintegrin and metalloproteinase with thrombospondin motifs 2; ADAM-TS 2; ADAM-TS2; ADAMTS-2; Procollagen I N-proteinase; PC I-NP; Procollagen I/II amino propeptide-processing enzyme; Procollagen N-endopeptidase; pNPI
UniProt Protein Function:ADAMTS2: Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis. Defects in ADAMTS2 are the cause of Ehlers-Danlos syndrome type 7C (EDS7C). EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS7C is marked by extremely fragile tissues, hyperextensible skin and easy bruising. Facial skin contains numerous folds, as in the cutis laxa syndrome. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.4.24.14; Extracellular matrix; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 5q35.3Cellular Component: extracellular regionMolecular Function: metalloendopeptidase activity; metallopeptidase activityDisease: Ehlers-danlos Syndrome, Type Vii, Autosomal Recessive
UniProt Protein Details:
NCBI Summary:This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature procollagen N-proteinase. This proteinase excises the N-propeptide of the fibrillar procollagens types I-III and type V. Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
UniProt Code:O95450
NCBI GenInfo Identifier:218511944
NCBI Gene ID:9509
NCBI Accession:O95450.2
UniProt Secondary Accession:O95450
UniProt Related Accession:O95450
Molecular Weight:135 kDa
NCBI Full Name:A disintegrin and metalloproteinase with thrombospondin motifs 2
NCBI Synonym Full Names:ADAM metallopeptidase with thrombospondin type 1 motif 2
NCBI Official Symbol:ADAMTS2  
NCBI Official Synonym Symbols:NPI; PNPI; PCINP; PCPNI; PCI-NP; PC I-NP; ADAM-TS2; ADAMTS-2; ADAMTS-3  
NCBI Protein Information:A disintegrin and metalloproteinase with thrombospondin motifs 2
UniProt Protein Name:A disintegrin and metalloproteinase with thrombospondin motifs 2
UniProt Synonym Protein Names:Procollagen I N-proteinase; PC I-NP; Procollagen I/II amino propeptide-processing enzyme; Procollagen N-endopeptidase; pNPI
Protein Family:A disintegrin and metalloproteinase with thrombospondin motifs
UniProt Gene Name:ADAMTS2  
UniProt Entry Name:
ELISA Kits
Human A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAMTS2) ELISA Kit
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