The ADAMTS19 Polyclonal Antibody (PAC018514) is a valuable tool for researchers interested in studying the ADAMTS19 protein, which plays a crucial role in extracellular matrix remodeling and tissue homeostasis. This antibody is produced in rabbits and exhibits high reactivity with human samples, making it suitable for use in Western blot applications. By targeting the ADAMTS19 protein, this antibody enables researchers to detect and analyze its expression in various cell types, making it an essential tool for studies in developmental biology and cardiovascular research.ADAMTS19 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family of proteases, known for their roles in processes such as angiogenesis, connective tissue organization, and inflammation.
ADAMTS19, in particular, is implicated in cardiac development and extracellular matrix regulation, making it a promising target for research into heart disease, vascular disorders, and other cardiovascular conditions. By elucidating the functions of ADAMTS19, researchers can gain insights into the pathogenesis of these diseases and potentially identify new therapeutic strategies.
Antibody Name:
ADAMTS19 Antibody (PACO18514)
Antibody SKU:
PACO18514
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human ADAMTS19
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO18514(ADAMTS19 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has high sequence similarity to the protein encoded by ADAMTS16, another family member.
Synonyms:
ADAM metallopeptidase with thrombospondin type 1 motif, 19
UniProt Protein Function:
ADAMTS19: Protein type: Secreted; Protease; Extracellular matrix; Secreted, signal peptide; EC 3.4.24.-; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 5q23.3
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has high sequence similarity to the protein encoded by ADAMTS16, another family member. [provided by RefSeq, Jul 2008]
