ADAMTS18 Antibody (PACO22123)
- SKU:
- PACO22123
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
ADAMTS18 Antibody (PACO22123)
The ADAMTS18 Polyclonal Antibody (PACO22123) is a valuable tool for researchers studying ADAMTS18, a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family of proteases. This antibody is produced in rabbits and demonstrates high reactivity with human samples, making it suitable for Western blot applications. By binding to the ADAMTS18 protein, this antibody allows for the detection and analysis of ADAMTS18 expression in various cell types, making it an essential component for studies in the fields of biology and pathology.ADAMTS18 is known for its involvement in extracellular matrix remodeling, angiogenesis, and inflammation, making it a promising target for research in various diseases, including cancer, cardiovascular disorders, and inflammatory conditions.
By understanding the function and regulatory mechanisms of ADAMTS18, researchers can gain insight into potential therapeutic strategies for targeting this protease in diseases where its dysregulation is implicated.In summary, the ADAMTS18 Polyclonal Antibody (PACO22123) offers researchers a reliable tool for investigating the role of ADAMTS18 in physiological and pathological processes, providing valuable insights that may lead to the development of novel treatments and interventions targeting this important protease.
| Antibody Name: | ADAMTS18 Antibody (PACO22123) |
| Antibody SKU: | PACO22123 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthesized peptide derived from internal of human ADAMTS18. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from 3T3 cells, using ADAMTS18 antibody. |
| Background: | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined. |
| Synonyms: | A disintegrin and metalloproteinase with thrombospondin motifs 18; ADAM-TS 18; ADAM-TS18; ADAMTS-18EC=3.4.24.-; |
| UniProt Protein Function: | ADAMTS18: Defects in ADAMTS18 are the cause of Knobloch syndrome type 2 (KNO2). A developmental disorder primarily characterized by typical eye abnormalities, including high myopia, cataracts, dislocated lens, vitreoretinal degeneration, and retinal detachment, with occipital skull defects, which can range from occipital encephalocele to occult cutis aplasia. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.24.-; Secreted; Protease; Motility/polarity/chemotaxis; Secreted, signal peptide Chromosomal Location of Human Ortholog: 16q23 Cellular Component: proteinaceous extracellular matrix Molecular Function:zinc ion binding; metalloendopeptidase activity Biological Process: eye development; proteolysis Disease: Microcornea, Myopic Chorioretinal Atrophy, And Telecanthus |
| NCBI Summary: | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8TE60 |
| NCBI GenInfo Identifier: | 40806187 |
| NCBI Gene ID: | 170692 |
| NCBI Accession: | NP_955387.1 |
| UniProt Secondary Accession: | Q8TE60,Q6P4R5, Q6ZWJ9, |
| UniProt Related Accession: | Q8TE60 |
| Molecular Weight: | 135,167 Da |
| NCBI Full Name: | A disintegrin and metalloproteinase with thrombospondin motifs 18 preproprotein |
| NCBI Synonym Full Names: | ADAM metallopeptidase with thrombospondin type 1 motif, 18 |
| NCBI Official Symbol: | ADAMTS18Â Â |
| NCBI Official Synonym Symbols: | KNO2; ADAMTS21Â Â |
| NCBI Protein Information: | A disintegrin and metalloproteinase with thrombospondin motifs 18; disintegrin and metalloprotease-like protein; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18; a disintegrin-like and metalloprotease (reproly |
| UniProt Protein Name: | A disintegrin and metalloproteinase with thrombospondin motifs 18 |
| Protein Family: | A disintegrin and metalloproteinase with thrombospondin motifs |
| UniProt Gene Name: | ADAMTS18Â Â |
| UniProt Entry Name: | ATS18_HUMAN |
| Antibodies | ELISA Kits |
| ADAMTS18 Antibody (PACO07236) | Human ADAMTS18 ELISA Kit |
| Human A disintegrin and metalloproteinase with thrombospondin motifs 18 (ADAMTS18) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
ADAMTS18 Antibody (PACO15316)
ADAMTS18 Antibody (PACO07236)
ADAMTS18 Antibody (PACO18513)
Human A disintegrin and metalloproteinase with thrombospondin motifs 18 (ADAMTS18) ELISA Kit (HUEB2445)
Mouse A disintegrin and metalloproteinase with thrombospondin motifs 18 (Adamts18) ELISA Kit (MOEB2194)
ompF Antibody (PACO64865)
