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ADAMTS18 Antibody (PACO22123)

SKU:
PACO22123
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€419
Frequently bought together:

Description

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ADAMTS18 Antibody (PACO22123)

The ADAMTS18 Polyclonal Antibody (PACO22123) is a valuable tool for researchers studying ADAMTS18, a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family of proteases. This antibody is produced in rabbits and demonstrates high reactivity with human samples, making it suitable for Western blot applications. By binding to the ADAMTS18 protein, this antibody allows for the detection and analysis of ADAMTS18 expression in various cell types, making it an essential component for studies in the fields of biology and pathology.ADAMTS18 is known for its involvement in extracellular matrix remodeling, angiogenesis, and inflammation, making it a promising target for research in various diseases, including cancer, cardiovascular disorders, and inflammatory conditions.

By understanding the function and regulatory mechanisms of ADAMTS18, researchers can gain insight into potential therapeutic strategies for targeting this protease in diseases where its dysregulation is implicated.In summary, the ADAMTS18 Polyclonal Antibody (PACO22123) offers researchers a reliable tool for investigating the role of ADAMTS18 in physiological and pathological processes, providing valuable insights that may lead to the development of novel treatments and interventions targeting this important protease.

Antibody Name:ADAMTS18 Antibody (PACO22123)
Antibody SKU:PACO22123
Size:100ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:Human, Mouse
Immunogen:Synthesized peptide derived from internal of human ADAMTS18.
Form:Liquid
Storage Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern blot analysis of extracts from 3T3 cells, using ADAMTS18 antibody.
Background:This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined.
Synonyms:A disintegrin and metalloproteinase with thrombospondin motifs 18; ADAM-TS 18; ADAM-TS18; ADAMTS-18EC=3.4.24.-;
UniProt Protein Function:ADAMTS18: Defects in ADAMTS18 are the cause of Knobloch syndrome type 2 (KNO2). A developmental disorder primarily characterized by typical eye abnormalities, including high myopia, cataracts, dislocated lens, vitreoretinal degeneration, and retinal detachment, with occipital skull defects, which can range from occipital encephalocele to occult cutis aplasia. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.4.24.-; Secreted; Protease; Motility/polarity/chemotaxis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 16q23

Cellular Component: proteinaceous extracellular matrix

Molecular Function:zinc ion binding; metalloendopeptidase activity

Biological Process: eye development; proteolysis

Disease: Microcornea, Myopic Chorioretinal Atrophy, And Telecanthus

NCBI Summary:This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
UniProt Code:Q8TE60
NCBI GenInfo Identifier:40806187
NCBI Gene ID:170692
NCBI Accession:NP_955387.1
UniProt Secondary Accession:Q8TE60,Q6P4R5, Q6ZWJ9,
UniProt Related Accession:Q8TE60
Molecular Weight:135,167 Da
NCBI Full Name:A disintegrin and metalloproteinase with thrombospondin motifs 18 preproprotein
NCBI Synonym Full Names:ADAM metallopeptidase with thrombospondin type 1 motif, 18
NCBI Official Symbol:ADAMTS18  
NCBI Official Synonym Symbols:KNO2; ADAMTS21  
NCBI Protein Information:A disintegrin and metalloproteinase with thrombospondin motifs 18; disintegrin and metalloprotease-like protein; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18; a disintegrin-like and metalloprotease (reproly
UniProt Protein Name:A disintegrin and metalloproteinase with thrombospondin motifs 18
Protein Family:A disintegrin and metalloproteinase with thrombospondin motifs
UniProt Gene Name:ADAMTS18  
UniProt Entry Name:ATS18_HUMAN
AntibodiesELISA Kits
ADAMTS18 Antibody (PACO07236)Human ADAMTS18 ELISA Kit
Human A disintegrin and metalloproteinase with thrombospondin motifs 18 (ADAMTS18) ELISA Kit
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