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ADAMTS18 Antibody (PACO18513)

SKU:
PACO18513
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339
Frequently bought together:

Description

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ADAMTS18 Antibody (PACO18513)

The ADAMTS18 Polyclonal Antibody (PAC018513) is a valuable tool for researchers studying the ADAMTS18 protein, a member of the ADAMTS (A Disintegrin And Metalloproteinase with ThromboSpondin motifs) family known for its role in extracellular matrix remodeling and tissue homeostasis. This antibody, generated in rabbits, shows high reactivity with human samples and is validated for use in Western blot applications.ADAMTS18 is implicated in various biological processes, including development, angiogenesis, and inflammation, making it a versatile target for investigation in fields such as developmental biology, cardiovascular research, and cancer biology.

By specifically binding to the ADAMTS18 protein, this antibody allows for precise detection and analysis of ADAMTS18 expression in different cell types, providing valuable insights into its functions and potential therapeutic implications.With its ability to support detailed studies on ADAMTS18 in both normal and pathological conditions, this antibody is an essential tool for researchers seeking to deepen their understanding of ADAMTS18 biology and its implications for human health.

Antibody Name:ADAMTS18 Antibody (PACO18513)
Antibody SKU:PACO18513
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:ELISA:1:1000-1:2000, WB:1:200-1:1000
Species Reactivity:Human, Mouse
Immunogen:Synthetic peptide of human ADAMTS18
Form:Liquid
Storage Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:Antigen affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageGel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Human prostate tissue, Primary antibody: PACO18513(ADAMTS18 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 minutes.
Background:This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined.
Synonyms:ADAM metallopeptidase with thrombospondin type 1 motif, 18
UniProt Protein Function:ADAMTS18: Defects in ADAMTS18 are the cause of Knobloch syndrome type 2 (KNO2). A developmental disorder primarily characterized by typical eye abnormalities, including high myopia, cataracts, dislocated lens, vitreoretinal degeneration, and retinal detachment, with occipital skull defects, which can range from occipital encephalocele to occult cutis aplasia. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.4.24.-; Secreted; Protease; Motility/polarity/chemotaxis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 16q23

Cellular Component: proteinaceous extracellular matrix

Molecular Function:zinc ion binding; metalloendopeptidase activity

Biological Process: eye development; proteolysis

Disease: Microcornea, Myopic Chorioretinal Atrophy, And Telecanthus

NCBI Summary:This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
UniProt Code:Q8TE60
NCBI GenInfo Identifier:40806187
NCBI Gene ID:170692
NCBI Accession:NP_955387.1
UniProt Secondary Accession:Q8TE60,Q6P4R5, Q6ZWJ9,
UniProt Related Accession:Q8TE60
Molecular Weight:135,167 Da
NCBI Full Name:A disintegrin and metalloproteinase with thrombospondin motifs 18 preproprotein
NCBI Synonym Full Names:ADAM metallopeptidase with thrombospondin type 1 motif, 18
NCBI Official Symbol:ADAMTS18  
NCBI Official Synonym Symbols:KNO2; ADAMTS21  
NCBI Protein Information:A disintegrin and metalloproteinase with thrombospondin motifs 18; disintegrin and metalloprotease-like protein; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18; a disintegrin-like and metalloprotease (reproly
UniProt Protein Name:A disintegrin and metalloproteinase with thrombospondin motifs 18
Protein Family:A disintegrin and metalloproteinase with thrombospondin motifs
UniProt Gene Name:ADAMTS18  
UniProt Entry Name:ATS18_HUMAN
AntibodiesELISA Kits
ADAMTS18 Antibody (PACO07236)Human ADAMTS18 ELISA Kit
Human A disintegrin and metalloproteinase with thrombospondin motifs 18 (ADAMTS18) ELISA Kit
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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