ADAMTS18 Antibody (PACO15316)
- SKU:
- PACO15316
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
ADAMTS18 Antibody (PACO15316)
The ADAMTS18 Antibody (PAC015316) is a polyclonal antibody designed for research involving ADAMTS18, a protease enzyme belonging to the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. ADAMTS18 plays a crucial role in extracellular matrix remodeling and has been implicated in various biological processes, including inflammation, tissue repair, and tumor progression.This antibody, raised in rabbits, is highly specific and reacts with human ADAMTS18 protein, making it ideal for use in Western blot and immunohistochemistry applications. It enables the detection and analysis of ADAMTS18 in various cell types and tissue samples, providing valuable insights into its functions and mechanisms of action.
Research on ADAMTS18 is relevant in the fields of cancer biology, wound healing, and tissue remodeling, as dysregulation of this enzyme has been associated with various disease conditions. Understanding the role of ADAMTS18 in these processes is essential for the development of targeted therapies and diagnostic tools for cancer and other related disorders.Overall, the ADAMTS18 Antibody (PAC015316) offers researchers a reliable tool for studying the functions and significance of ADAMTS18 in biological and pathological processes, paving the way for advancements in biomedical research and clinical applications.
| Antibody Name: | ADAMTS18 Antibody (PACO15316) |
| Antibody SKU: | PACO15316 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Fusion protein of human ADAMTS18 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO15316(ADAMTS18 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO15316(ADAMTS18 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined. |
| Synonyms: | ADAM metallopeptidase with thrombospondin type 1 motif, 18 |
| UniProt Protein Function: | ADAMTS18: Defects in ADAMTS18 are the cause of Knobloch syndrome type 2 (KNO2). A developmental disorder primarily characterized by typical eye abnormalities, including high myopia, cataracts, dislocated lens, vitreoretinal degeneration, and retinal detachment, with occipital skull defects, which can range from occipital encephalocele to occult cutis aplasia. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.24.-; Secreted; Protease; Motility/polarity/chemotaxis; Secreted, signal peptide Chromosomal Location of Human Ortholog: 16q23 Cellular Component: proteinaceous extracellular matrix Molecular Function:zinc ion binding; metalloendopeptidase activity Biological Process: eye development; proteolysis Disease: Microcornea, Myopic Chorioretinal Atrophy, And Telecanthus |
| NCBI Summary: | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8TE60 |
| NCBI GenInfo Identifier: | 40806187 |
| NCBI Gene ID: | 170692 |
| NCBI Accession: | NP_955387.1 |
| UniProt Secondary Accession: | Q8TE60,Q6P4R5, Q6ZWJ9, |
| UniProt Related Accession: | Q8TE60 |
| Molecular Weight: | 135,167 Da |
| NCBI Full Name: | A disintegrin and metalloproteinase with thrombospondin motifs 18 preproprotein |
| NCBI Synonym Full Names: | ADAM metallopeptidase with thrombospondin type 1 motif, 18 |
| NCBI Official Symbol: | ADAMTS18Â Â |
| NCBI Official Synonym Symbols: | KNO2; ADAMTS21Â Â |
| NCBI Protein Information: | A disintegrin and metalloproteinase with thrombospondin motifs 18; disintegrin and metalloprotease-like protein; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18; a disintegrin-like and metalloprotease (reproly |
| UniProt Protein Name: | A disintegrin and metalloproteinase with thrombospondin motifs 18 |
| Protein Family: | A disintegrin and metalloproteinase with thrombospondin motifs |
| UniProt Gene Name: | ADAMTS18Â Â |
| UniProt Entry Name: | ATS18_HUMAN |
| Antibodies | ELISA Kits |
| ADAMTS18 Antibody (PACO07236) | Human ADAMTS18 ELISA Kit |
| Human A disintegrin and metalloproteinase with thrombospondin motifs 18 (ADAMTS18) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
ADAMTS18 Antibody (PACO07236)
ADAMTS18 Antibody (PACO22123)
ADAMTS18 Antibody (PACO18513)
Human A disintegrin and metalloproteinase with thrombospondin motifs 18 (ADAMTS18) ELISA Kit (HUEB2445)
Mouse A disintegrin and metalloproteinase with thrombospondin motifs 18 (Adamts18) ELISA Kit (MOEB2194)
