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ADAMTS18 Antibody (PACO07236)

SKU:
PACO07236
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • ADAMTS18 Antibody PACO07236
  • ADAMTS18 Antibody PACO07236
  • ADAMTS18 Antibody PACO07236
€269
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Description

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ADAMTS18 Antibody (PACO07236)

The ADAMTS18 Polyclonal Antibody (PACO07236) is a key tool for researchers studying the ADAMTS18 protein, a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family involved in extracellular matrix remodeling and tissue homeostasis. This antibody, produced using rabbit immunization, exhibits high specificity and sensitivity for human samples, making it an excellent choice for Western blot and immunohistochemistry applications.ADAMTS18 is known for its role in modulating cell adhesion, migration, and proliferation, with implications in various physiological and pathological processes, including development, wound healing, and cancer progression. The ADAMTS18 Polyclonal Antibody enables precise detection and quantification of ADAMTS18 protein levels in different cell types and tissues, facilitating detailed investigations in fields such as developmental biology, tissue engineering, and oncology.

By utilizing this antibody, researchers can gain valuable insights into the functions and mechanisms of ADAMTS18, paving the way for novel therapeutic strategies targeting this protein in diseases characterized by dysregulated extracellular matrix dynamics and tissue remodeling. The ADAMTS18 Polyclonal Antibody is a valuable tool for advancing our understanding of ADAMTS18 biology and its potential as a therapeutic target in various disease contexts.

Antibody Name:ADAMTS18 Antibody (PACO07236)
Antibody SKU:PACO07236
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:ELISA:1:10000, WB:1:500-1:2000, IHC-p:1:100-1:300
Species Reactivity:Human, Mouse
Immunogen:Synthesized peptide derived from the C-terminal region of human ADAMTS-18. at AA rangle: 1030-1110
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageImmunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:200.
Product ImageImmunohistochemical analysis of paraffin-embedded human-skin, antibody was diluted at 1:200.
Product ImageWestern blot analysis of 3T3 using ADAMTS-18 antibody. Secondary antibody was diluted at 1:20000.
Synonyms:ADAMTS18; ADAMTS21; A disintegrin and metalloproteinase with thrombospondin motifs 18; ADAM-TS 18; ADAM-TS18; ADAMTS-18
UniProt Protein Function:ADAMTS18: Defects in ADAMTS18 are the cause of Knobloch syndrome type 2 (KNO2). A developmental disorder primarily characterized by typical eye abnormalities, including high myopia, cataracts, dislocated lens, vitreoretinal degeneration, and retinal detachment, with occipital skull defects, which can range from occipital encephalocele to occult cutis aplasia. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.4.24.-; Secreted; Protease; Motility/polarity/chemotaxis; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 16q23

Cellular Component: proteinaceous extracellular matrix

Molecular Function:zinc ion binding; metalloendopeptidase activity

Biological Process: eye development; proteolysis

Disease: Microcornea, Myopic Chorioretinal Atrophy, And Telecanthus

NCBI Summary:This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
UniProt Code:Q8TE60
NCBI GenInfo Identifier:40806187
NCBI Gene ID:170692
NCBI Accession:NP_955387.1
UniProt Secondary Accession:Q8TE60,Q6P4R5, Q6ZWJ9,
UniProt Related Accession:Q8TE60
Molecular Weight:135,167 Da
NCBI Full Name:A disintegrin and metalloproteinase with thrombospondin motifs 18 preproprotein
NCBI Synonym Full Names:ADAM metallopeptidase with thrombospondin type 1 motif, 18
NCBI Official Symbol:ADAMTS18  
NCBI Official Synonym Symbols:KNO2; ADAMTS21  
NCBI Protein Information:A disintegrin and metalloproteinase with thrombospondin motifs 18; disintegrin and metalloprotease-like protein; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18; a disintegrin-like and metalloprotease (reproly
UniProt Protein Name:A disintegrin and metalloproteinase with thrombospondin motifs 18
Protein Family:A disintegrin and metalloproteinase with thrombospondin motifs
UniProt Gene Name:ADAMTS18  
UniProt Entry Name:ATS18_HUMAN
ELISA Kits
Human ADAMTS18 ELISA Kit
Human A disintegrin and metalloproteinase with thrombospondin motifs 18 (ADAMTS18) ELISA Kit
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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