ADAMTS18 Antibody (PACO07236)
- SKU:
- PACO07236
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
ADAMTS18 Antibody (PACO07236)
The ADAMTS18 Polyclonal Antibody (PACO07236) is a key tool for researchers studying the ADAMTS18 protein, a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family involved in extracellular matrix remodeling and tissue homeostasis. This antibody, produced using rabbit immunization, exhibits high specificity and sensitivity for human samples, making it an excellent choice for Western blot and immunohistochemistry applications.ADAMTS18 is known for its role in modulating cell adhesion, migration, and proliferation, with implications in various physiological and pathological processes, including development, wound healing, and cancer progression. The ADAMTS18 Polyclonal Antibody enables precise detection and quantification of ADAMTS18 protein levels in different cell types and tissues, facilitating detailed investigations in fields such as developmental biology, tissue engineering, and oncology.
By utilizing this antibody, researchers can gain valuable insights into the functions and mechanisms of ADAMTS18, paving the way for novel therapeutic strategies targeting this protein in diseases characterized by dysregulated extracellular matrix dynamics and tissue remodeling. The ADAMTS18 Polyclonal Antibody is a valuable tool for advancing our understanding of ADAMTS18 biology and its potential as a therapeutic target in various disease contexts.
Antibody Name: | ADAMTS18 Antibody (PACO07236) |
Antibody SKU: | PACO07236 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:10000, WB:1:500-1:2000, IHC-p:1:100-1:300 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthesized peptide derived from the C-terminal region of human ADAMTS-18. at AA rangle: 1030-1110 |
Form: | Liquid |
Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:200. | |
Immunohistochemical analysis of paraffin-embedded human-skin, antibody was diluted at 1:200. | |
Western blot analysis of 3T3 using ADAMTS-18 antibody. Secondary antibody was diluted at 1:20000. |
Synonyms: | ADAMTS18; ADAMTS21; A disintegrin and metalloproteinase with thrombospondin motifs 18; ADAM-TS 18; ADAM-TS18; ADAMTS-18 |
UniProt Protein Function: | ADAMTS18: Defects in ADAMTS18 are the cause of Knobloch syndrome type 2 (KNO2). A developmental disorder primarily characterized by typical eye abnormalities, including high myopia, cataracts, dislocated lens, vitreoretinal degeneration, and retinal detachment, with occipital skull defects, which can range from occipital encephalocele to occult cutis aplasia. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 3.4.24.-; Secreted; Protease; Motility/polarity/chemotaxis; Secreted, signal peptide Chromosomal Location of Human Ortholog: 16q23 Cellular Component: proteinaceous extracellular matrix Molecular Function:zinc ion binding; metalloendopeptidase activity Biological Process: eye development; proteolysis Disease: Microcornea, Myopic Chorioretinal Atrophy, And Telecanthus |
NCBI Summary: | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q8TE60 |
NCBI GenInfo Identifier: | 40806187 |
NCBI Gene ID: | 170692 |
NCBI Accession: | NP_955387.1 |
UniProt Secondary Accession: | Q8TE60,Q6P4R5, Q6ZWJ9, |
UniProt Related Accession: | Q8TE60 |
Molecular Weight: | 135,167 Da |
NCBI Full Name: | A disintegrin and metalloproteinase with thrombospondin motifs 18 preproprotein |
NCBI Synonym Full Names: | ADAM metallopeptidase with thrombospondin type 1 motif, 18 |
NCBI Official Symbol: | ADAMTS18 |
NCBI Official Synonym Symbols: | KNO2; ADAMTS21 |
NCBI Protein Information: | A disintegrin and metalloproteinase with thrombospondin motifs 18; disintegrin and metalloprotease-like protein; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18; a disintegrin-like and metalloprotease (reproly |
UniProt Protein Name: | A disintegrin and metalloproteinase with thrombospondin motifs 18 |
Protein Family: | A disintegrin and metalloproteinase with thrombospondin motifs |
UniProt Gene Name: | ADAMTS18 |
UniProt Entry Name: | ATS18_HUMAN |
ELISA Kits |
Human ADAMTS18 ELISA Kit |
Human A disintegrin and metalloproteinase with thrombospondin motifs 18 (ADAMTS18) ELISA Kit |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |