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ADAMTS17 Antibody (PACO19062)

SKU:
PACO19062
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
  • ADAMTS17 Antibody PACO19062
  • ADAMTS17 Antibody PACO19062
  • ADAMTS17 Antibody PACO19062
€339
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Description

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ADAMTS17 Antibody (PACO19062)

The ADAMTS17 Polyclonal Antibody (PACO19062) is a powerful tool for researchers studying ADAMTS17, a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family involved in extracellular matrix remodeling and tissue morphogenesis. This antibody, derived from rabbit hosts, is highly specific for human samples and has been validated for use in Western blotting applications. By binding to the ADAMTS17 protein, this antibody enables precise detection and analysis in a wide range of cell types, making it ideal for investigations in areas such as developmental biology and tissue remodeling.

ADAMTS17 is a key player in processes such as collagen degradation, angiogenesis, and tissue repair, making it a crucial target for research into conditions like arthritis, cardiovascular diseases, and developmental disorders. Understanding the function and regulation of ADAMTS17 can provide valuable insights into pathological mechanisms and potential therapeutic strategies for various diseases. Researchers can use this antibody to delve deeper into the role of ADAMTS17 in normal physiology and disease conditions, paving the way for innovative treatment approaches and medical advancements.

Antibody Name:ADAMTS17 Antibody (PACO19062)
Antibody SKU:PACO19062
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100
Species Reactivity:Human, Mouse
Immunogen:Synthetic peptide of human ADAMTS17
Form:Liquid
Storage Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:Antigen affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO19062(ADAMTS17 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: x200).
Product ImageGel: 8%SDS-PAGE, Lysate: 40 μg, Lane: NIH/3T3 cells, Primary antibody: PACO19062(ADAMTS17 Antibody) at dilution 1/1200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 hour.
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO19062(ADAMTS17 Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by ADAMTS19, another family member. The function of this protein has not been determined.
Synonyms:ADAM metallopeptidase with thrombospondin type 1 motif, 17
UniProt Protein Function:ADAMTS17: Defects in ADAMTS17 are the cause of Weill-Marchesani- like syndrome (WMLS). It is a disorder characterized by many of the key features of Weill-Marchesani syndrome, including lenticular myopia, ectopia lentis, glaucoma, spherophakia and short stature. However, the characteristic brachydactyly or decreased joint flexibility of Weill-Marchesani syndrome are absent. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 3.4.24.-; Secreted; Secreted, signal peptide; Protease; Motility/polarity/chemotaxisChromosomal Location of Human Ortholog: 15q24Disease: Weill-marchesani-like Syndrome
UniProt Protein Details:
NCBI Summary:This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may promote breast cancer cell growth and survival. Mutations in this gene are associated with a Weill-Marchesani-like syndrome, which is characterized by lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature. [provided by RefSeq, May 2016]
UniProt Code:Q8TE56
NCBI GenInfo Identifier:296434401
NCBI Gene ID:170691
NCBI Accession:Q8TE56.2
UniProt Secondary Accession:Q8TE56,Q2I7G4, Q6ZN75
UniProt Related Accession:Q8TE56
Molecular Weight:54,757 Da
NCBI Full Name:A disintegrin and metalloproteinase with thrombospondin motifs 17
NCBI Synonym Full Names:ADAM metallopeptidase with thrombospondin type 1 motif 17
NCBI Official Symbol:ADAMTS17  
NCBI Official Synonym Symbols:
NCBI Protein Information:A disintegrin and metalloproteinase with thrombospondin motifs 17
UniProt Protein Name:A disintegrin and metalloproteinase with thrombospondin motifs 17
UniProt Synonym Protein Names:
Protein Family:A disintegrin and metalloproteinase with thrombospondin motifs
UniProt Gene Name:ADAMTS17  
UniProt Entry Name:ATS17_HUMAN
Antibodies
ADAMTS17 Antibody (PACO03573)
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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