The ADAMTS16 Polyclonal Antibody (PACO19060) is a valuable tool for researchers studying the role of ADAMTS16, a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family of proteins, in various biological processes. This antibody, produced in rabbits, has high reactivity with human samples and has been validated for use in Western blot assays.ADAMTS16 is known to be involved in the processing and modulation of extracellular matrix components, playing a role in tissue development, maintenance, and remodeling. Dysregulation of ADAMTS16 has been linked to various diseases, including cancer, cardiovascular disorders, and inflammatory conditions.
Therefore, understanding the function and regulation of ADAMTS16 is important for uncovering its potential as a therapeutic target.By utilizing the ADAMTS16 Polyclonal Antibody, researchers can detect and analyze ADAMTS16 protein expression in different cell types and tissue samples, providing key insights into its biological functions. This antibody is a valuable tool for studies in the fields of cell biology, molecular biology, and disease research, offering new avenues for exploration and discovery in the realm of ADAMTS16-mediated biology.
Antibody Name:
ADAMTS16 Antibody (PACO19060)
Antibody SKU:
PACO19060
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human ADAMTS16
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO19060(ADAMTS16 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO19060(ADAMTS16 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has high sequence similarity to the protein encoded by ADAMTS18, another family member.
Synonyms:
ADAM metallopeptidase with thrombospondin type 1 motif, 16
UniProt Protein Function:
ADAMTS16: 2 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted; Protease; Motility/polarity/chemotaxis; EC 3.4.24.-; Secreted, signal peptideChromosomal Location of Human Ortholog: 5p15Cellular Component: proteinaceous extracellular matrixMolecular Function: zinc ion binding; metalloendopeptidase activityBiological Process: ureteric bud branching; proteolysis
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has high sequence similarity to the protein encoded by ADAMTS18, another family member. [provided by RefSeq, Jul 2008]
A disintegrin and metalloproteinase with thrombospondin motifs 16 preproprotein
NCBI Synonym Full Names:
ADAM metallopeptidase with thrombospondin type 1 motif, 16
NCBI Official Symbol:
ADAMTS16Â Â
NCBI Official Synonym Symbols:
ADAMTS16s Â
NCBI Protein Information:
A disintegrin and metalloproteinase with thrombospondin motifs 16; ADAM-TS 16; ADAM-TS16; ADAMTS-16; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 16
UniProt Protein Name:
A disintegrin and metalloproteinase with thrombospondin motifs 16
UniProt Synonym Protein Names:
Protein Family:
A disintegrin and metalloproteinase with thrombospondin motifs
