The ADAMTS15 Polyclonal Antibody (PACO58328) is a cutting-edge research tool designed for scientists studying ADAMTS15, a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family of enzymes. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the ADAMTS15 protein, researchers can detect and analyze its presence in various cell types, making it an ideal tool for studies in biology and medical research.ADAMTS15 has been implicated in extracellular matrix degradation, cell migration, and angiogenesis, making it a key player in processes such as tissue development and wound healing.
Its role in these biological functions has sparked interest in its potential involvement in various diseases, including cancer and cardiovascular disorders. By elucidating the function of ADAMTS15, researchers aim to uncover novel therapeutic targets and strategies for the treatment of these debilitating conditions.The ADAMTS15 Polyclonal Antibody (PACO58328) offers researchers a powerful tool to explore the functions and mechanisms of ADAMTS15 in health and disease. With its high specificity and sensitivity, this antibody is a valuable asset for those seeking to advance their understanding of ADAMTS15 biology and its implications in human health.
Antibody Name:
ADAMTS15 Antibody (PACO58328)
Antibody SKU:
PACO58328
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:200-1:500
Species Reactivity:
Human
Immunogen:
Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 15 protein (801-913AA)
IHC image of PACO58328 diluted at 1:400 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Synonyms:
A disintegrin and metalloproteinase with thrombospondin motifs 15 (ADAM-TS 15) (ADAM-TS15) (ADAMTS-15) (EC 3.4.24), ADAMTS15
UniProt Protein Function:
ADAMTS15: Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted; EC 3.4.24.-; Protease; Extracellular matrixChromosomal Location of Human Ortholog: 11q25
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme, which may play a role in versican processing during skeletal muscle development. This gene may function as a tumor suppressor in colorectal and breast cancers. [provided by RefSeq, May 2016]
