The ADAMTS15 Polyclonal Antibody (PACO14105) is a valuable tool for researchers studying ADAMTS15, a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family of proteins. ADAMTS15 is involved in various biological processes, including extracellular matrix remodeling, angiogenesis, and inflammation, making it a key player in the regulation of tissue homeostasis.Raised in rabbits, this antibody is highly specific and reactive with human samples, making it suitable for use in Western blot applications. By binding to ADAMTS15, this antibody enables researchers to detect and analyze the protein in a variety of cell types.
Its versatility and reliability make it ideal for studies in fields such as biology, biochemistry, and pharmacology.ADAMTS15 has been implicated in the pathogenesis of several diseases, including cancer, arthritis, and cardiovascular disorders. Understanding the function and regulation of ADAMTS15 is crucial for developing targeted therapies that can modulate its activity in disease states. With the ADAMTS15 Polyclonal Antibody (PACO14105), researchers can accelerate their studies and contribute to advancements in the field of biomedical research.
Antibody Name:
ADAMTS15 Antibody (PACO14105)
Antibody SKU:
PACO14105
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human ADAMTS15
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO14105(ADAMTS15 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO14105(ADAMTS15 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the proteins encoded by ADAMTS1 and ADAMTS8.
Synonyms:
ADAM metallopeptidase with thrombospondin type 1 motif, 15
UniProt Protein Function:
ADAMTS15: Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted; EC 3.4.24.-; Protease; Extracellular matrixChromosomal Location of Human Ortholog: 11q25
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme, which may play a role in versican processing during skeletal muscle development. This gene may function as a tumor suppressor in colorectal and breast cancers. [provided by RefSeq, May 2016]
