The ADAMTS15 Polyclonal Antibody (PACO14104) is a valuable tool for researchers studying ADAMTS15, a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family of proteins. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the ADAMTS15 protein, this antibody enables accurate detection and analysis in various cell types, making it ideal for studies in the fields of extracellular matrix biology, tissue remodeling, and cancer research.
ADAMTS15 is known to play a crucial role in the regulation of extracellular matrix organization and remodeling, making it a promising target for research into diseases such as cancer, arthritis, and vascular disorders. Understanding the function of ADAMTS15 is essential for developing therapeutic strategies that target the extracellular matrix and its associated processes. The ADAMTS15 Polyclonal Antibody provides researchers with a powerful tool to further investigate the role of ADAMTS15 in health and disease.
Antibody Name:
ADAMTS15 Antibody (PACO14104)
Antibody SKU:
PACO14104
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human ADAMTS15
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO14104(ADAMTS15 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO14104(ADAMTS15 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the proteins encoded by ADAMTS1 and ADAMTS8.
Synonyms:
ADAM metallopeptidase with thrombospondin type 1 motif, 15
UniProt Protein Function:
ADAMTS15: Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted; EC 3.4.24.-; Protease; Extracellular matrixChromosomal Location of Human Ortholog: 11q25
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme, which may play a role in versican processing during skeletal muscle development. This gene may function as a tumor suppressor in colorectal and breast cancers. [provided by RefSeq, May 2016]
