The ADAMTS14 Polyclonal Antibody (PACO19058) is a vital tool for researchers studying the ADAMTS14 protein, a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family involved in extracellular matrix remodeling and tissue homeostasis. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples and is validated for use in various applications, including Western blotting.ADAMTS14 has been linked to various pathological conditions such as arthritis, cancer, and cardiovascular disease, making it a promising target for therapeutic interventions.
By targeting ADAMTS14, researchers can gain insights into its role in disease progression and potentially develop strategies to modulate its activity for therapeutic purposes.This antibody enables researchers to detect and analyze ADAMTS14 expression in different cell types, providing valuable information for studies in molecular biology, cell biology, and disease mechanisms. Understanding the function of ADAMTS14 is essential for advancing our knowledge of extracellular matrix dynamics and its implications in disease pathology.
Antibody Name:
ADAMTS14 Antibody (PACO19058)
Antibody SKU:
PACO19058
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human ADAMTS14
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO19058(ADAMTS14 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. This gene is highly similar to two family members, ADAMTS2 and ADAMTS3, in its sequence and gene structure, and the encoded protein shares the aminoprocollagen peptidase activity with the protein products encoded by ADAMTS2 and ADAMTS3. Various transcript variants of this gene have been identified. They result from the use of two different promoters and transcription initiation sites as well as alternative splicing sites. The full length nature of some transcripts has not been defined.
Synonyms:
ADAM metallopeptidase with thrombospondin type 1 motif, 14
UniProt Protein Function:
Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity.
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme cleaves amino-terminal propeptides from type I procollagen, a necessary step in the formation of collagen fibers. Mutations in this gene may be associated with osteoarthritis in human patients. [provided by RefSeq, May 2016]
