The ADAMTS13 Polyclonal Antibody (CAB8482) is specifically designed for research involving the ADAMTS13 protein, an enzyme responsible for cleaving von Willebrand factor in the blood. The antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications such as Western blot and immunohistochemistry.ADAMTS13 plays a crucial role in preventing blood clots by regulating the size of von Willebrand factor. Dysregulation of ADAMTS13 activity has been associated with thrombotic disorders such as thrombotic thrombocytopenic purpura (TTP).
Therefore, the ADAMTS13 Polyclonal Antibody is a valuable tool for researchers studying coagulation disorders and developing potential therapies for related conditions.With its high specificity and sensitivity, this antibody enables the detection and analysis of ADAMTS13 in different tissue types and disease states. By studying the function and regulation of ADAMTS13, researchers can gain insights into its role in maintaining normal hemostasis and its potential as a therapeutic target for bleeding and clotting disorders.
Product Name:
ADAMTS13 Rabbit Polyclonal Antibody
SKU:
CAB8482
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 50-300 of human ADAMTS13 (NP_620594.1).
This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
11093
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ADAMTS13 antibody (CAB8482) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
