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ADAMTS12 Antibody (PACO05429)

SKU:
PACO05429
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$323

Description

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ADAMTS12 Antibody (PACO05429)

The ADAMTS12 Polyclonal Antibody (PACO05429) is a valuable tool for researchers studying the ADAMTS12 protein, which is involved in extracellular matrix remodeling and tissue growth. This antibody, produced in rabbits, exhibits high specificity and sensitivity for human samples, making it ideal for use in Western blot applications. By binding to the ADAMTS12 protein, this antibody allows for the detection and analysis of ADAMTS12 in various cell types, providing insight into its role in processes such as development, wound healing, and disease progression.ADAMTS12 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family of proteins, known for their involvement in proteolytic processing and modification of extracellular matrix components.

ADAMTS12 has been implicated in various diseases and conditions, including arthritis, cancer, and cardiovascular disorders, making it a promising target for research in these areas. Understanding the function and regulation of ADAMTS12 is essential for developing therapeutic interventions that target its activity in disease pathways.Overall, the ADAMTS12 Polyclonal Antibody (PACO05429) serves as a valuable tool for researchers studying the roles and mechanisms of ADAMTS12 in health and disease. Its high specificity, sensitivity, and versatility make it a reliable reagent for investigating the functions of this important protein in various biological contexts.

Antibody Name:ADAMTS12 Antibody (PACO05429)
Antibody SKU:PACO05429
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:20000, IHC:1:100-1:300
Species Reactivity:Human
Immunogen:Synthesized peptide derived from the Internal region of human ADAMTS-12.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:ADAMTS12; A disintegrin and metalloproteinase with thrombospondin motifs 12; ADAM-TS 12; ADAM-TS12; ADAMTS-12
UniProt Protein Function:ADAMTS12: Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.4.24.-; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide; Protease

Chromosomal Location of Human Ortholog: 5q35

Cellular Component: extracellular matrix; proteinaceous extracellular matrix

Molecular Function:protein binding; zinc ion binding; metalloendopeptidase activity

Biological Process: cell migration; proteolysis involved in cellular protein catabolic process; cell-matrix adhesion; negative regulation of chondrocyte differentiation; regulation of inflammatory response; proteoglycan catabolic process

NCBI Summary:This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq, Jul 2008]
UniProt Code:P58397
NCBI GenInfo Identifier:51558724
NCBI Gene ID:81792
NCBI Accession:NP_112217.2
UniProt Secondary Accession:P58397,Q6UWL3, A2RRN9, A5D6V6,
UniProt Related Accession:P58397
Molecular Weight:168,460 Da
NCBI Full Name:A disintegrin and metalloproteinase with thrombospondin motifs 12 preproprotein
NCBI Synonym Full Names:ADAM metallopeptidase with thrombospondin type 1 motif, 12
NCBI Official Symbol:ADAMTS12  
NCBI Official Synonym Symbols:PRO4389  
NCBI Protein Information:A disintegrin and metalloproteinase with thrombospondin motifs 12
UniProt Protein Name:A disintegrin and metalloproteinase with thrombospondin motifs 12
Protein Family:Disintegrin and metalloproteinase domain-containing protein
UniProt Gene Name:ADAMTS12  
UniProt Entry Name:ATS12_HUMAN

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