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ADAMTS12 Antibody (PACO05429)

SKU:
PACO05429
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
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Description

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Antibody Name:ADAMTS12 Antibody (PACO05429)
Antibody SKU:PACO05429
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:20000, IHC:1:100-1:300
Species Reactivity:Human
Immunogen:Synthesized peptide derived from the Internal region of human ADAMTS-12.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:ADAMTS12; A disintegrin and metalloproteinase with thrombospondin motifs 12; ADAM-TS 12; ADAM-TS12; ADAMTS-12
UniProt Protein Function:ADAMTS12: Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.4.24.-; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide; Protease

Chromosomal Location of Human Ortholog: 5q35

Cellular Component: extracellular matrix; proteinaceous extracellular matrix

Molecular Function:protein binding; zinc ion binding; metalloendopeptidase activity

Biological Process: cell migration; proteolysis involved in cellular protein catabolic process; cell-matrix adhesion; negative regulation of chondrocyte differentiation; regulation of inflammatory response; proteoglycan catabolic process

NCBI Summary:This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq, Jul 2008]
UniProt Code:P58397
NCBI GenInfo Identifier:51558724
NCBI Gene ID:81792
NCBI Accession:NP_112217.2
UniProt Secondary Accession:P58397,Q6UWL3, A2RRN9, A5D6V6,
UniProt Related Accession:P58397
Molecular Weight:168,460 Da
NCBI Full Name:A disintegrin and metalloproteinase with thrombospondin motifs 12 preproprotein
NCBI Synonym Full Names:ADAM metallopeptidase with thrombospondin type 1 motif, 12
NCBI Official Symbol:ADAMTS12  
NCBI Official Synonym Symbols:PRO4389  
NCBI Protein Information:A disintegrin and metalloproteinase with thrombospondin motifs 12
UniProt Protein Name:A disintegrin and metalloproteinase with thrombospondin motifs 12
Protein Family:Disintegrin and metalloproteinase domain-containing protein
UniProt Gene Name:ADAMTS12  
UniProt Entry Name:ATS12_HUMAN

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