ADAMTS12 Antibody (PACO24763)
- SKU:
- PACO24763
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
ADAMTS12 Antibody (PACO24763)
The ADAMTS12 Polyclonal Antibody (PAC024763) is a valuable tool for researchers studying the ADAMTS12 protein, a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family known for its role in extracellular matrix remodeling and tissue homeostasis. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the ADAMTS12 protein, this antibody enables precise detection and analysis in various cell types, making it ideal for studies in cell biology and tissue remodeling research.ADAMTS12 is a crucial enzyme involved in the modulation of extracellular matrix components, such as collagens and proteoglycans, making it essential for tissue development and maintenance.
Dysregulation of ADAMTS12 has been linked to various pathological conditions, including arthritis, cardiovascular diseases, and cancer. Understanding the function and regulation of ADAMTS12 is essential for advancing therapeutic strategies targeting these diseases and promoting tissue repair and regeneration.Overall, the ADAMTS12 Polyclonal Antibody offers researchers a reliable tool for studying the intricate role of ADAMTS12 in tissue remodeling, providing insights into its potential as a therapeutic target for a range of diseases.
| Antibody Name: | ADAMTS12 Antibody (PACO24763) |
| Antibody SKU: | PACO24763 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human A disintegrin and metalloproteinase with thrombospondin motifs 12 protein (26-229AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO24763 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human brain tissue using PACO24763 at dilution of 1:100. |
| Background: | Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties. |
| Synonyms: | A disintegrin and metalloproteinase with thrombospondin motifs 12 (ADAM-TS 12) (ADAM-TS12) (ADAMTS-12) (EC 3.4.24.-), ADAMTS12 |
| UniProt Protein Function: | ADAMTS12: Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.24.-; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide; Protease Chromosomal Location of Human Ortholog: 5q35 Cellular Component: extracellular matrix; proteinaceous extracellular matrix Molecular Function:protein binding; zinc ion binding; metalloendopeptidase activity Biological Process: cell migration; proteolysis involved in cellular protein catabolic process; cell-matrix adhesion; negative regulation of chondrocyte differentiation; regulation of inflammatory response; proteoglycan catabolic process |
| NCBI Summary: | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P58397 |
| NCBI GenInfo Identifier: | 51558724 |
| NCBI Gene ID: | 81792 |
| NCBI Accession: | NP_112217.2 |
| UniProt Secondary Accession: | P58397,Q6UWL3, A2RRN9, A5D6V6, |
| UniProt Related Accession: | P58397 |
| Molecular Weight: | 168,460 Da |
| NCBI Full Name: | A disintegrin and metalloproteinase with thrombospondin motifs 12 preproprotein |
| NCBI Synonym Full Names: | ADAM metallopeptidase with thrombospondin type 1 motif, 12 |
| NCBI Official Symbol: | ADAMTS12Â Â |
| NCBI Official Synonym Symbols: | PRO4389Â Â |
| NCBI Protein Information: | A disintegrin and metalloproteinase with thrombospondin motifs 12 |
| UniProt Protein Name: | A disintegrin and metalloproteinase with thrombospondin motifs 12 |
| Protein Family: | Disintegrin and metalloproteinase domain-containing protein |
| UniProt Gene Name: | ADAMTS12Â Â |
| UniProt Entry Name: | ATS12_HUMAN |
| Antibodies | ELISA Kits |
| ADAMTS12 Antibody (PACO05429) | Human ADAMTS12 / A Disintegrin And Metalloase With Thrombospondin 12 ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
ADAMTS12 Antibody (PACO05429)
Human ADAMTS12 / A Disintegrin And Metalloase With Thrombospondin 12 ELISA Kit
