The ADAMTS10 Polyclonal Antibody (PACO19055) is a valuable tool for researchers studying the ADAMTS10 protein, a member of the ADAMTS (A Disintegrin And Metalloproteinase with Thrombospondin motifs) family of enzymes implicated in extracellular matrix remodeling and various biological processes. This antibody, produced in rabbits, has high specificity for human samples and has been validated for use in Western blot applications.ADAMTS10 is known for its involvement in tissue development and maintenance, particularly in the context of skeletal and connective tissue formation.
Dysregulation of ADAMTS10 has been linked to diseases such as arthritis, cancer, and cardiovascular disorders, highlighting its importance as a potential therapeutic target. The ADAMTS10 Polyclonal Antibody enables researchers to detect and analyze ADAMTS10 expression in different cell types, facilitating investigations into its role in these pathological conditions and offering insights into potential treatment strategies.
Antibody Name:
ADAMTS10 Antibody (PACO19055)
Antibody SKU:
PACO19055
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human ADAMTS10
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO19055(ADAMTS10 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO19055(ADAMTS10 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome.
Synonyms:
ADAM metallopeptidase with thrombospondin type 1 motif, 10
UniProt Protein Function:
Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues.
UniProt Protein Details:
NCBI Summary:
This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome. [provided by RefSeq, Jul 2008]
