The ADAMTS1 Polyclonal Antibody (PAC020984) is a powerful tool for researchers studying ADAMTS1, an enzyme involved in extracellular matrix remodeling and implicated in various disease processes. This antibody, produced in rabbits, boasts high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the ADAMTS1 protein, researchers can easily detect and analyze its expression in a variety of cell types, making it an essential component for studies in biology and disease pathology.ADAMTS1, a member of the ADAMTS family of proteases, plays a crucial role in tissue development, angiogenesis, and inflammation. Dysregulation of ADAMTS1 has been linked to various pathological conditions, including cancer, arthritis, and cardiovascular diseases.
By elucidating the function of ADAMTS1, researchers can gain valuable insights into the molecular mechanisms driving these diseases, potentially leading to the development of novel therapies and diagnostic tools.Overall, the ADAMTS1 Polyclonal Antibody is a valuable asset for researchers looking to deepen their understanding of ADAMTS1 biology and its implications in human health and disease. Its specificity and reliability make it an invaluable tool for investigating the role of ADAMTS1 in various physiological and pathological processes.
Antibody Name:
ADAMTS1 Antibody (PACO20984)
Antibody SKU:
PACO20984
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human ADAMTS1
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20984(ADAMTS1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO20984(ADAMTS1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function.
Synonyms:
ADAM metallopeptidase with thrombospondin type 1 motif, 1
UniProt Protein Function:
ADAMTS1: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.
UniProt Protein Details:
Protein type:Protease; Secreted, signal peptide; Motility/polarity/chemotaxis; EC 3.4.24.-; Secreted
Molecular Function:heparin binding; metalloendopeptidase activity; metallopeptidase activity; zinc ion binding
Biological Process: integrin-mediated signaling pathway; kidney development; negative regulation of cell proliferation; ovulation from ovarian follicle; proteolysis
NCBI Summary:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008]
