The ADAMTS1 Polyclonal Antibody (CAB15356) is a powerful tool for researchers studying ADAMTS1, a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family of proteases. ADAMTS1 is known to play a key role in extracellular matrix remodeling, angiogenesis, and inflammation, making it a valuable target for studies in cancer, cardiovascular disease, and tissue repair.This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. It binds to the ADAMTS1 protein, enabling accurate detection and analysis in a variety of cell types.
With its high reactivity and specificity, the ADAMTS1 Polyclonal Antibody is an essential tool for researchers investigating the functions and pathways involving ADAMTS1.Given the role of ADAMTS1 in various physiological and pathological processes, such as tumor growth, neovascularization, and tissue repair, understanding its expression, regulation, and functions are crucial for developing potential therapeutic strategies. The ADAMTS1 Polyclonal Antibody provides researchers with a reliable and sensitive tool to further explore the complex functions of ADAMTS1 in both health and disease.
Product Name:
ADAMTS1 Rabbit Polyclonal Antibody
SKU:
CAB15356
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 718-967 of human ADAMTS1 (NP_008919.3).
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function.
Purification Method:
Affinity purification
Gene ID:
9510
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ADAMTS1 antibody (CAB15356) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
