The ADAM8 Polyclonal Antibody (CAB10497) is a powerful tool for researchers studying ADAM8, a cell surface protein involved in various physiological processes such as cell adhesion, migration, and inflammation. This antibody is raised in rabbits and exhibits high reactivity with human samples, making it an excellent choice for Western blot applications.ADAM8, a member of the ADAM (a disintegrin and metalloproteinase) family, is known for its role in proteolytic processing of cell surface proteins and extracellular matrix components. Its dysregulation has been implicated in various diseases, including cancer, inflammation, and asthma. By targeting ADAM8 with this polyclonal antibody, researchers can detect and analyze protein levels in different cell types, shedding light on its function and potential as a therapeutic target.
The ADAM8 Polyclonal Antibody is an essential tool for studies in immunology, cancer research, and inflammation. With its ability to specifically bind to ADAM8 protein, this antibody enables researchers to investigate its involvement in disease development and progression. By understanding the mechanisms of ADAM8 action, novel strategies for therapeutic intervention may be developed to combat diseases associated with dysregulated ADAM8 activity.
Product Name:
ADAM8 Rabbit Polyclonal Antibody
SKU:
CAB10497
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 17-300 of human ADAM8 (NP_001100.3).
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene may be involved in cell adhesion during neurodegeneration, and it is thought to be a target for allergic respiratory diseases, including asthma. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
101
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ADAM8 antibody (CAB10497) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
