The ADAM7 Polyclonal Antibody (PAC015310) is a valuable tool for researchers investigating ADAM7, a cell surface molecule involved in various cellular processes, including cell adhesion, migration, and proteolysis. This antibody, produced in rabbits, exhibits high reactivity towards human samples and has been validated for use in Western blot applications. By specifically binding to the ADAM7 protein, this antibody enables precise detection and analysis in different cell types, making it a versatile tool for studies in cell biology and cancer research.ADAM7, also known as a disintegrin and metalloproteinase domain-containing protein, plays a crucial role in modulating cellular functions by cleaving cell surface proteins and impacting signaling pathways.
Its involvement in various cellular processes makes it a promising target for research into diseases like cancer, cardiovascular disorders, and neurodegenerative conditions. Investigating the function of ADAM7 is essential for developing potential therapeutic interventions that target its activity and influence cellular behavior in specific disease contexts.
Antibody Name:
ADAM7 Antibody (PACO15310)
Antibody SKU:
PACO15310
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Fusion protein of human ADAM7
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO15310(ADAM7 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15310(ADAM7 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a member of the ADAMs family of zinc proteases. These transmembrane proteins play roles in multiple processes including cell signaling, adhesion and migration. The encoded protein lacks protease activity and may play roles in protein-protein interactions and cell adhesion processes including sperm-egg fusion. Mutations in this gene may be involved in the progression of melanoma.
Synonyms:
ADAM metallopeptidase domain 7
UniProt Protein Function:
May play an important role in male reproduction including sperm maturation and gonadotrope function. This is a non catalytic metalloprotease-like protein ().
