The ADAM29 Antibody (PAC019057) is a valuable tool for researchers studying the ADAM29 protein, a member of the ADAM (A Disintegrin And Metalloproteinase) family known for its role in cell adhesion and proteolytic processing of proteins. This antibody, produced using a polyclonal antibody approach, is highly specific for human samples and has been validated for use in Western blot applications.ADAM29 has been implicated in various biological processes, including cell migration, cell signaling, and immune response regulation. Its overexpression has been associated with cancer progression and metastasis, making it a promising target for cancer research.
By utilizing the ADAM29 Antibody, researchers can accurately detect and quantify ADAM29 protein levels in different cell types, providing valuable insights for studies in oncology and cell biology.With its high reactivity and specificity, the ADAM29 Antibody offers a reliable tool for investigating the functional role of ADAM29 in normal physiological processes and disease states. Gain a deeper understanding of ADAM29 and its potential implications in cancer and other disorders with the help of this validated research antibody.
Antibody Name:
ADAM29 Antibody (PACO19057)
Antibody SKU:
PACO19057
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human ADAM29
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO19057(ADAM29 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO19057(ADAM29 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is highly expressed in testis and may be involved in human spermatogenesis. Alternative splicing results in multiple transcript variants that encode the same protein.
Synonyms:
ADAM metallopeptidase domain 29
UniProt Protein Function:
ADAM29: a member of the ADAM (a disintegrin and metalloprotease domain) family of Cancer-Testis Antigen (CTAs). CTAs may play roles in embryonal development and tumor transformation or aspects of tumor progression. CTAs were once thought to be silenced in most normal adult tissues, with limited expression in fetal, placental, testis, and ovarian cells. These proteins are now known to be aberrantly expressed in various cancers and many are capable of eliciting humoral and cellular immune responses. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins. May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein. Has been found to be frequently mutated in melanoma. Mutations may play a role in melanoma progression and metastasis. Expressed in leukemias at the mRNA level. Three isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:Protease; Cancer Testis Antigen (CTA); Motility/polarity/chemotaxis; Membrane protein, integral
Chromosomal Location of Human Ortholog: 4q34
Cellular Component: integral to plasma membrane
Molecular Function:zinc ion binding; metallopeptidase activity; metalloendopeptidase activity
Biological Process: spermatogenesis; proteolysis
NCBI Summary:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is highly expressed in testis and may be involved in human spermatogenesis. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]
