The ADAM28 Polyclonal Antibody (CAB14849) is an essential tool for researchers studying ADAM28, a member of the ADAM (a disintegrin and metalloproteinase) family of proteins involved in cell adhesion, migration, and proteolysis. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications, allowing for the detection and analysis of ADAM28 protein expression in various cell types.ADAM28 has been shown to play a role in various physiological processes, including cell migration, cell signaling, and extracellular matrix remodeling. Dysregulation of ADAM28 expression has been implicated in various diseases, making it an attractive target for therapeutic intervention.
The ADAM28 Polyclonal Antibody enables researchers to investigate the function and regulation of ADAM28 in different disease contexts, particularly in cancer, inflammation, and tissue remodeling.By understanding the role of ADAM28, researchers can potentially uncover novel therapeutic targets and strategies for treating diseases associated with dysregulated ADAM28 expression. The ADAM28 Polyclonal Antibody is a valuable tool for advancing research in the fields of cancer biology, immunology, and molecular medicine.
Product Name:
ADAM28 Rabbit Polyclonal Antibody
SKU:
CAB14849
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 199-440 of human ADAM28 (NP_055080.2).
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
87kDa
Observed MW:
87kDa
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein. This gene is present in a gene cluster with other members of the ADAM family on chromosome 8. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
10863
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ADAM28 Rabbit pAb (CAB14849) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
