The ADAM22 Polyclonal Antibody (CAB10030) is a valuable tool for researchers studying ADAM22, a transmembrane protein involved in synaptic transmission and neuronal development. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the ADAM22 protein, this antibody enables the detection and analysis of ADAM22 expression in various cell types, making it an ideal choice for studies in neurobiology and neuroscience research.ADAM22 plays a crucial role in mediating synaptic transmission and regulating neuronal function, making it a key player in processes such as synaptic plasticity and learning and memory. Dysfunction of ADAM22 has been linked to neurological disorders such as epilepsy and schizophrenia, highlighting the importance of understanding its molecular mechanisms and signaling pathways.
By investigating the role of ADAM22, researchers can gain insights into the pathogenesis of these disorders and potentially identify new therapeutic targets for treatment.Overall, the ADAM22 Polyclonal Antibody (CAB10030) is a valuable asset for researchers interested in elucidating the functions and implications of ADAM22 in neuronal physiology and neurological disorders. Its high specificity and reactivity make it a reliable tool for investigating the intricate mechanisms underlying synaptic transmission and neuronal development.
Product Name:
ADAM22 Rabbit Polyclonal Antibody
SKU:
CAB10030
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 223-400 of human ADAM22 (NP_004185.1).
Cell projection, Membrane, Single-pass type I membrane protein, axon.
Calculated MW:
100kDa
Observed MW:
100kDa
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.
Purification Method:
Affinity purification
Gene ID:
53616
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ADAM22 antibody (CAB10030) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
