The ADAM21 Polyclonal Antibody (PAC015312) is a crucial tool for researchers studying ADAM21, a cell surface protein involved in various cellular processes, including cell adhesion, migration, and proteolysis. This antibody, produced through immunization of rabbits, shows high specificity and sensitivity towards human samples, making it suitable for Western blot applications.ADAM21, a member of the A Disintegrin and Metalloproteinase (ADAM) family, is known for its role in cell-cell interactions and signaling pathways. Its involvement in processes such as fertilization, embryogenesis, and neurogenesis highlights its significance in developmental biology and disease pathology. The ADAM21 Polyclonal Antibody enables precise detection and analysis of ADAM21 protein expression in different cell types, offering valuable insights for research in cell biology, neuroscience, and reproductive health.
Researchers interested in exploring the functions and mechanisms of ADAM21 in various physiological and pathological contexts, such as cancer, neurodegenerative disorders, and reproductive disorders, can benefit from the versatility and reliability of the ADAM21 Polyclonal Antibody. By understanding the diverse roles of ADAM21 in cellular physiology, researchers can elucidate its potential as a therapeutic target for intervention in diseases and disorders related to cell signaling and communication.
Antibody Name:
ADAM21 Antibody (PACO15312)
Antibody SKU:
PACO15312
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:15-1:50
Species Reactivity:
Human
Immunogen:
Fusion protein of human ADAM21
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO15312(ADAM21 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15312(ADAM21 Antibody) at dilution 1/15, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The expression of this gene expression is testis-specific.
Synonyms:
ADAM metallopeptidase domain 21
UniProt Protein Function:
ADAM21: May be involved in sperm maturation and/or fertilization. May also be involved in epithelia functions associated with establishing and maintaining gradients of ions or nutrients.Protein type: EC 3.4.24.-; Protease; Motility/polarity/chemotaxis; Membrane protein, integralChromosomal Location of Human Ortholog: 14q24.1Cellular Component: plasma membraneMolecular Function: metallopeptidase activityBiological Process: binding of sperm to zona pellucida; single fertilization
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The expression of this gene expression is testis-specific. [provided by RefSeq, May 2011]
